Finegoldia is a genus of Gram-positive bacteria. They are anaerobic cocci of the class Clostridia, with Finegoldia magna being the type species.[1] F. magna was formerly known, along with several other Gram-positive anaerobic cocci (GPACs), as Peptostreptococcus magnus, but was moved into its own genus in 1999.[2][3] The name is in honor of Sydney M. Finegold, an American microbiologist, while magna is Latin for large.[1] It is an opportunistic human pathogen that normally colonizes skin and mucous membranes.[4] It is often seen in biofilms on chronic ulcers such as in diabetic foot or decubitus ulcers.[3] Most surveys have found it to be susceptible to penicillins, carbapenems and metronidazole, though resistant strains have been identified.[5] Resistance to clindamycin is common and has been seen in over 10% of isolates in the US.[3][6] One review stated that "the combination of diminished antimicrobial susceptibility, its prevalence, and the described virulence factors gives F. magna a special position among the GPAC."[5]
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References
edit- ^ a b "Finegoldia". LPSN. Retrieved 2016-01-06.
- ^ Murdoch, D. A; Shah, H. N (1999-10-01). "Reclassification of Peptostreptococcus magnus (Prevot 1933) Holdeman and Moore 1972 as Finegoldia magna comb. nov. and Peptostreptococcus micros (Prevot 1933) Smith 1957 as Micromonas micros comb. nov". Anaerobe. 5 (5): 555–559. doi:10.1006/anae.1999.0197.
- ^ a b c John e. Bennett, MD; Raphael Dolin, MD; Martin j. Blaser, MD (2014-08-28). "Anaerobic Cocci and Anaerobic Gram-Positive Nonsporulating Bacilli". Mandell, Douglas, and Bennett's principles and practice of infectious diseases. ISBN 978-1-4557-4801-3.
- ^ de Moreuil, Claire; Héry-Arnaud, Geneviève; David, Charles-Henri; Provost, Bastien; Mondine, Philippe; Alavi, Zarrin; de Saint Martin, Luc; Bezon, Eric; Berre, Rozenn Le (2015-04-01). "Finegoldia magna, not a well-known infectious agent of bacteriemic post-sternotomy mediastinitis". Anaerobe. 32: 32–33. doi:10.1016/j.anaerobe.2014.11.012. PMID 25448620.
- ^ a b Veloo, A. C. M.; Welling, G. W.; Degener, J. E. (2011-03-01). "Antimicrobial Susceptibility of Clinically Relevant Gram-Positive Anaerobic Cocci Collected over a Three-Year Period in the Netherlands". Antimicrobial Agents and Chemotherapy. 55 (3): 1199–1203. doi:10.1128/AAC.01771-09. ISSN 0066-4804. PMC 3067104. PMID 21189338.
- ^ Brazier, J. S.; Hall, V.; Morris, T. E.; Gal, M.; Duerden, B. I. (2003-08-01). "Antibiotic susceptibilities of Gram-positive anaerobic cocci: results of a sentinel study in England and Wales". Journal of Antimicrobial Chemotherapy. 52 (2): 224–228. doi:10.1093/jac/dkg316. ISSN 0305-7453. PMID 12837734.