Fire in the Blood may refer to:
- Fire in the Blood, UK title of 1954 French film La Rage au corps
- Fire in the Blood, 1990 single by British band Matt Bianco
- Fire in the Blood, title of English translation of novel Chaleur du Sang by Irène Némirovsky, published posthumously in 2007
- Brimstone Angels: Fire in the Blood, title of a fantasy novel from the series The Brimstone Angels by Erin M. Evans, published in 2014
- Fire in the Blood (2013 film), documentary film
- Fire in the Blood (1953 film), a 1953 Spanish drama film