Flunitrazolam

Flunitrazolam
Legal status
Legal status	BR: Class B1 (Psychoactive drugs); CA: Schedule IV; DE: NpSG (Industrial and scientific use only); UK: Under Psychoactive Substances Act;
Identifiers
	IUPAC name 1-methyl-8-nitro-6-(2-fluorophenyl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine;
CAS Number	2243815-18-9 ;
PubChem CID	137700379;
ChemSpider	59718543;
UNII	OK0I6HTR1Y;
CompTox Dashboard (EPA)	DTXSID601024059 ;
Chemical and physical data
Formula	C17H12FN5O2
Molar mass	337.314 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=[N](=O)c4ccc2-n1c(C)nnc1CN=C(c2c4)c3ccccc3F;
	InChI InChI=1S/C17H12FN5O2/c1-10-20-21-16-9-19-17(12-4-2-3-5-14(12)18)13-8-11(23(24)25)6-7-15(13)22(10)16/h2-8H,9H2,1H3; Key:RDLAGIOILLWVTM-UHFFFAOYSA-N;

Flunitrazolam (FNTZ, Flunazolam) is a triazolobenzodiazepine (TBZD), which are benzodiazepine (BZD) derivatives, that has been sold online as a designer drug, and is a potent hypnotic and sedative drug similar to related compounds such as flunitrazepam, clonazolam and flubromazolam. It was first definitively identified and reported to the EMCDDA Early Warning System, by an analytical laboratory in Germany in October 2016,^[2] and had not been described in the scientific or patent literature before this.^[3] It is the triazole analogue of Flunitrazepam (Rohypnol). The addition of the triazole ring to the scaffold increases potency significantly, this is evident as flunitrazolam is reported anecdotally to be active in the microgram level. It is active at 0.1 mg.^[4]^[5]

References

^ Anvisa (2024-05-28). "RDC Nº 877 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 877 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União. Archived from the original on 2024-09-25. Retrieved 2024-09-25.
^ "Europol 2016 Annual Report on the implementation of Council Decision 2005/387/JHA" (PDF).
^ Cornett EM, Novitch MB, Brunk AJ, Davidson KS, Menard BL, Urman RD, Kaye AD (June 2018). "New benzodiazepines for sedation". Best Practice & Research. Clinical Anaesthesiology. 32 (2): 149–164. doi:10.1016/j.bpa.2018.06.007. PMID 30322456. S2CID 53501694.
^ Ameline A, Richeval C, Gaulier JM, Raul JS, Kintz P (July 2018). "Characterization of Flunitrazolam, a New Designer Benzodiazepine, in Oral Fluid After a Controlled Single Administration". Journal of Analytical Toxicology. 42 (6): e58–e60. doi:10.1093/jat/bky012. PMID 29462316.
^ Ameline A, Richeval C, Gaulier JM, Raul JS, Kintz P (February 2019). "Detection of the designer benzodiazepine flunitrazolam in urine and preliminary data on its metabolism". Drug Testing and Analysis. 11 (2): 223–229. doi:10.1002/dta.2480. PMID 30109775. S2CID 52001932.

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[1] Anvisa (2024-05-28). "RDC Nº 877 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 877 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União. Archived from the original on 2024-09-25. Retrieved 2024-09-25.

[2] "Europol 2016 Annual Report on the implementation of Council Decision 2005/387/JHA" (PDF).

[3] Cornett EM, Novitch MB, Brunk AJ, Davidson KS, Menard BL, Urman RD, Kaye AD (June 2018). "New benzodiazepines for sedation". Best Practice & Research. Clinical Anaesthesiology. 32 (2): 149–164. doi:10.1016/j.bpa.2018.06.007. PMID 30322456. S2CID 53501694.

[pmid29462316-4] Ameline A, Richeval C, Gaulier JM, Raul JS, Kintz P (July 2018). "Characterization of Flunitrazolam, a New Designer Benzodiazepine, in Oral Fluid After a Controlled Single Administration". Journal of Analytical Toxicology. 42 (6): e58–e60. doi:10.1093/jat/bky012. PMID 29462316.

[pmid30109775-5] Ameline A, Richeval C, Gaulier JM, Raul JS, Kintz P (February 2019). "Detection of the designer benzodiazepine flunitrazolam in urine and preliminary data on its metabolism". Drug Testing and Analysis. 11 (2): 223–229. doi:10.1002/dta.2480. PMID 30109775. S2CID 52001932.

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Legal status

Legal status	BR: Class B1 (Psychoactive drugs)^[1] CA: Schedule IV DE: NpSG (Industrial and scientific use only) UK: Under Psychoactive Substances Act
Identifiers
IUPAC name 1-methyl-8-nitro-6-(2-fluorophenyl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
CAS Number	2243815-18-9^Y
PubChem CID	137700379
ChemSpider	59718543
UNII	OK0I6HTR1Y
CompTox Dashboard (EPA)	DTXSID601024059
Chemical and physical data
Formula	C₁₇H₁₂FN₅O₂
Molar mass	337.314 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=[N](=O)c4ccc2-n1c(C)nnc1CN=C(c2c4)c3ccccc3F
InChI InChI=1S/C17H12FN5O2/c1-10-20-21-16-9-19-17(12-4-2-3-5-14(12)18)13-8-11(23(24)25)6-7-15(13)22(10)16/h2-8H,9H2,1H3 Key:RDLAGIOILLWVTM-UHFFFAOYSA-N

Flunitrazolam

See also

References