Focal proliferative nephritis is a type of glomerulonephritis seen in 20% to 35% of cases of lupus nephritis, classified as type III. As the name suggests, lesions are seen in less than half of the glomeruli. Typically, one or two foci within an otherwise normal glomerulus show swelling and proliferation of endothelial and mesangial cells, infiltration by neutrophils, and/or fibrinoid deposits with capillary thrombi. Focal glomerulonephritis is usually associated with only mild microscopic hematuria and proteinuria; a transition to a more diffuse form of renal involvement is associated with more severe disease.[1]
| Focal proliferative nephritis | |
|---|---|
| Other names | Focal mesangial proliferative glomerulonephritis |
| Specialty | Nephrology |
Epidemiology
editIn cases of IgA nephropathy, focal proliferative glomerulonephritis is observed in about 20–50% of renal biopsy specimens. Twenty to sixty percent of patients with lupus who underwent renal biopsies exhibit focal proliferative or mesangial lupus nephritis.[2]
See also
editReferences
edit- ^ Robbins, Stanley L.; Kumar, Vinay (2007). Robbins basic pathology. Saunders/Elsevier. p. 142. ISBN 978-0-8089-2366-4.
- ^ Timson, David J.; Reece, Richard J.; Thoden, James B.; Holden, Hazel M.; L. Utz, Andrea; Biller, Beverly M. K.; Strehle, Eugen-Matthias; Böhm, Markus; Luger, Thomas A.; Leung, Alexander K. C.; Wong, Andrew L.; Donner, Markus G.; Häussinger, Dieter; Mann, Nirmal S.; Schmitt, Marcus; Leung, Alexander K. C.; Robson, William Lane M.; Wong, Andrew L.; Balwani, Manisha; Prakash-Cheng*, Ainu; Desnick, Robert J.; Lerche, Holger; Scheffer, Ingrid E.; Berkovic, Samuel F.; Lobnig, Brigitte M.; Jansen, Peter L. M.; Waldegger, Siegfried; Lang, Florian; Cate, Hugo ten; Thieme, Hagen; Weller, Michael; Schütte, Bärbel; Fass, Ronnie; Kato, Hideki; Nangaku, Masaomi; Kato, Hideki; Nangaku, Masaomi; Chang, Anthony; Kadambi, Pradeep V.; Alexander, Jessy J.; Ronco, Pierre; Debiec, Hanna; Hugo, Christian; Lobnig, Brigitte M.; Lobnig, Brigitte M.; Schnog, John-John B.; Gerdes, Victor E. A.; Francis, Jean; Geller, David S.; Brockmann, Knut; Wang, Dong; Vivo, Darryl C.; Kölker, Stefan; Kölker, Stefan; Erasmus, Elardus; Mienie, Lodewyk J.; Vissing, John; Reuser, Arnold; Correia, Catherine E.; Weinstein, David A.; Wolfsdorf, Joseph I.; Shin, Yoon S.; Hesselink, Reinout P.; Drost, Maarten R.; Wagenmakers, Anton J. M.; Vusse, Ger J.; Kiechl, Stefan; Denecke, Jonas; Schepers, Ute; Kolter, Thomas; Sandhoff, Konrad; Martin, Dianna C.; Triggs-Raine, Barbara L.; Sancak, Seda; Paschke, Ralf; Borza, Dorin-Bogdan; Ständer, Sonja; Traupe, Heiko; Becker, Michael A.; Straaten, Hanneke M.; Verdonck, Leo F.; Cate, Hugo Ten; Mempel, Martin; Abeck, Dietrich; Ghanem, Ismat; Hage, Samer El; Bode, Johannes G.; Fleisher, Thomas A.; Holland, Steven M.; Myers, Bennett; Herrmann, David; Kraiem, Zaki; Tomer, Yaron; Davies, Terry F.; White, James G.; Stöckler-Ipsiroglu, Sylvia; Stoll, Guido; Toyka, Klaus V.; Lamounier-Zepter, Valéria; Ruether, Klaus (2009). "Glomerulonephritis, Focal Proliferative". Encyclopedia of Molecular Mechanisms of Disease. Berlin, Heidelberg: Springer Berlin Heidelberg. pp. 709–711. doi:10.1007/978-3-540-29676-8_644. ISBN 978-3-540-67136-7.
Further reading
edit- Magil, Alex B.; Ballon, Henry S.; Rae, Angus (1982). "Focal proliferative lupus nephritis". The American Journal of Medicine. 72 (4). Elsevier BV: 620–630. doi:10.1016/0002-9343(82)90463-6. ISSN 0002-9343. PMID 7041645.
- Weening, Jan J.; D’Agati, Vivette D.; Schwartz, Melvin M.; Seshan, Surya V.; Alpers, Charles E.; Appel, Gerald B.; Balow, James E.; Bruijn, Jan A.; Cook, Terence; Ferrario, Franco; Fogo, Agnes B.; Ginzler, Ellen M.; Hebert, Lee; Hill, Gary; Hill, Prue; Jennette, J. Charles; Kong, Norella C.; Lesavre, Philippe; Lockshin, Michael; Looi, Lai-Meng; Makino, Hirofumi; Moura, Luiz A.; Nagata, Michio (2004). "The Classification of Glomerulonephritis in Systemic Lupus Erythematosus Revisited". Journal of the American Society of Nephrology. 15 (2). Ovid Technologies (Wolters Kluwer Health): 241–250. doi:10.1097/01.asn.0000108969.21691.5d. hdl:20.500.12648/8229. ISSN 1046-6673. PMID 14747370.