In enzymology, a formate—dihydrofolate ligase (EC 6.3.4.17) is an enzyme that catalyzes the chemical reaction
Formate—dihydrofolate ligase | |||||||||
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Identifiers | |||||||||
EC no. | 6.3.4.17 | ||||||||
CAS no. | 123303-25-3 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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- ATP + formate + dihydrofolate ADP + phosphate + 10-formyldihydrofolate
The 3 substrates of this enzyme are ATP, formate, and dihydrofolate, whereas its 3 products are ADP, phosphate, and 10-formyldihydrofolate.
This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is formate:dihydrofolate ligase (ADP-forming).
References
editFurther reading
edit- Drake JC, Baram J, Allegra CJ (1990). "Isolation and characterization of a novel dihydrofolate formylating enzyme from human MCF-7 breast cancer cells" (PDF). Biochem. Pharmacol. 39 (3): 615–8. doi:10.1016/0006-2952(90)90073-T. PMID 2306274.