Fotretamine

Fotretamine
Clinical data
Other names	Fotrin; Photrin; 2,2,4,4,6-Pentaethyleneimino-6-morpholino-cyclotriphosphazatriene
Drug class	Alkylating antineoplastic agent; Immunosuppressant
Identifiers
	IUPAC name 4-[2,4,4,6,6-pentakis(aziridin-1-yl)-1,3,5-triaza-2λ5,4λ5,6λ5-triphosphacyclohexa-1,3,5-trien-2-yl]morpholine;
CAS Number	37132-72-2;
PubChem CID	65800;
ChemSpider	59216;
UNII	7Z7670589C;
ChEMBL	ChEMBL471525;
CompTox Dashboard (EPA)	DTXSID5048687 ;
Chemical and physical data
Formula	C14H28N9OP3
Molar mass	431.361 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CN1P2(=NP(=NP(=N2)(N3CC3)N4CCOCC4)(N5CC5)N6CC6)N7CC7;
	InChI InChI=1S/C14H28N9OP3/c1-2-18(1)25(19-3-4-19)15-26(20-5-6-20,21-7-8-21)17-27(16-25,22-9-10-22)23-11-13-24-14-12-23/h1-14H2; Key:SCGZIPCHOAVGCL-UHFFFAOYSA-N;

Fotretamine (INNTooltip International Nonproprietary Name), also known as fotrin, is an alkylating antineoplastic and immunosuppressant.^[1]^[2] The drug entered clinical trials in the Soviet Union.^[3] It was first described in the literature by 1972.^[1]^[2]

References

^ ^a ^b Elks J (2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. p. 581. ISBN 978-1-4757-2085-3. Retrieved 17 October 2024.
^ ^a ^b Buckingham J (1996). Dictionary of Organic Compounds. Chapman & Hall. p. 3250. ISBN 978-0-412-54090-5. Retrieved 17 October 2024.
^ van de Grampel JC (1992). "Selected chemistry of cyclophosphazenes and cyclothiaphosphazenes". Coordination Chemistry Reviews. 112. Elsevier BV: 247–271. doi:10.1016/0010-8545(92)80012-g. ISSN 0010-8545.

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