Frain is a surname. Notable people with the surname include:
- David Frain (born 1962), an English footballer
- James Frain (born 1968), an English actor
- John Frain (born 1968), an English footballer, brother of Peter
- Peter Frain, an English footballer, brother of John
- Rose Frain, a British artist
- Todd Frain (born 1962), an American football player
See also
edit- Darren DeFrain (born 1967), an American author