Francisco Contreras may refer to:
- Francisco Contreras Valenzuela (1877–1933), Chilean writer
- Francisco Contreras (athlete) (1904–1949), Mexican Olympic hurdler
- Francisco Contreras (tennis) (born 1934), Mexican tennis player
- Francisco Contreras (boxer) (born 1984), Dominican professional boxer
- Francisco Contreras (footballer) (born 1999), Mexican footballer