Friedelin synthase (EC 5.4.99.50) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, friedelin-forming).[1] This enzyme catalyses the following chemical reaction
| Friedelin synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 5.4.99.50 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- (3S)-2,3-epoxy-2,3-dihydrosqualene friedelin
The enzyme from Kalanchoe daigremontiana also gives traces of other triterpenoids.
References
edit- ^ Wang Z, Yeats T, Han H, Jetter R (September 2010). "Cloning and characterization of oxidosqualene cyclases from Kalanchoe daigremontiana: enzymes catalyzing up to 10 rearrangement steps yielding friedelin and other triterpenoids". The Journal of Biological Chemistry. 285 (39): 29703–12. doi:10.1074/jbc.m109.098871. PMC 2943309. PMID 20610397.
External links
edit- Friedelin+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
