Frizzled-8 (Fz-8) is a protein that in humans is encoded by the FZD8 gene.[5][6]

FZD8
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFZD8, FZ-8, hFZ8, frizzled class receptor 8
External IDsOMIM: 606146; MGI: 108460; HomoloGene: 40606; GeneCards: FZD8; OMA:FZD8 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_031866

NM_008058

RefSeq (protein)

NP_114072

NP_032084

Location (UCSC)Chr 10: 35.64 – 35.64 MbChr 18: 9.21 – 9.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177283Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036904Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Saitoh T, Hirai M, Katoh M (Apr 2001). "Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2". Int J Oncol. 18 (5): 991–6. doi:10.3892/ijo.18.5.991. PMID 11295046.
  6. ^ a b "Entrez Gene: FZD8 frizzled homolog 8 (Drosophila)".

Further reading

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  • "Frizzled Receptors: FZD8". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2014-09-03. Retrieved 2008-12-04.
  • Overview of all the structural information available in the PDB for UniProt: Q9H461 (Human Frizzled-8 (FZD8)) at the PDBe-KB.


This article incorporates text from the United States National Library of Medicine, which is in the public domain.