GAS2L1

GAS2-like protein 1 is a protein that in humans is encoded by the GAS2L1 gene.

GAS2L1
Identifiers
Aliases	GAS2L1, GAR22, growth arrest specific 2 like 1
External IDs	OMIM: 602128; MGI: 1926176; HomoloGene: 4733; GeneCards: GAS2L1; OMA:GAS2L1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q12.2 Start 29,306,582 bp End 29,312,785 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 A1 Start 5,004,132 bp End 5,015,327 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium tendon of biceps brachii seminal vesicula endothelial cell Region I of hippocampus proper dorsal motor nucleus of vagus nerve olfactory bulb Brodmann area 23 primary visual cortex parotid gland Top expressed in otic vesicle blood lip seminiferous tubule internal carotid artery olfactory epithelium skin of external ear external carotid artery endothelial cell of lymphatic vessel stroma of bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytoskeletal anchor activity thyroid hormone receptor binding microtubule binding Cellular component cytoplasm microtubule cytoskeleton stress fiber Biological process cellular response to starvation negative regulation of microtubule depolymerization negative regulation of cell growth microtubule bundle formation negative regulation of gene expression negative regulation of erythrocyte differentiation cellular response to thyroid hormone stimulus regulation of cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10634 78926 Ensembl ENSG00000185340 ENSMUSG00000034201 UniProt Q99501 Q8JZP9 RefSeq (mRNA) NM_001278730 NM_006478 NM_152236 NM_152237 NM_001362985 NM_001395196 NM_001395197 NM_001190406 NM_001190408 NM_030228 NM_144560 RefSeq (protein) NP_001265659 NP_006469 NP_689422 NP_689423 NP_001349914 NP_001177335 NP_001177337 NP_084504 NP_653146 Location (UCSC) Chr 22: 29.31 – 29.31 Mb Chr 11: 5 – 5.02 Mb PubMed search
Wikidata
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The protein encoded by this gene, a member of the GAS2 family, is similar in sequence to the mouse protein Gas2, an actin-associated protein expressed at high levels in growth-arrested cells. Expression of the mouse Gas2 gene is negatively regulated by serum and growth factors. Three transcript variants encoding two different isoforms have been found for this gene.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Weinmann AS, Yan PS, Oberley MJ, et al. (2002). "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis". Genes Dev. 16 (2): 235–44. doi:10.1101/gad.943102. PMC 155318. PMID 11799066.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.