GRIP and coiled-coil domain-containing protein 2 is a protein that in humans is encoded by the GCC2 gene.[4][5]

GCC2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGCC2, GCC185, RANBP2L4, REN53, GRIP and coiled-coil domain containing 2
External IDsOMIM: 612711; MGI: 1917547; HomoloGene: 45639; GeneCards: GCC2; OMA:GCC2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_181453

NM_027375

RefSeq (protein)

NP_852118

n/a

Location (UCSC)Chr 2: 108.45 – 108.51 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a peripheral membrane protein localized to the trans-Golgi network. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135968Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Luke MR, Kjer-Nielsen L, Brown DL, Stow JL, Gleeson PA (Feb 2003). "GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network". J Biol Chem. 278 (6): 4216–26. doi:10.1074/jbc.M210387200. PMID 12446665.
  5. ^ a b "Entrez Gene: GCC2 GRIP and coiled-coil domain containing 2".

Further reading

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