GDP-mannose:cellobiosyl-diphosphopolyprenol alpha-mannosyltransferase (EC 2.4.1.252, GumH, AceA, alpha1,3-mannosyltransferase AceA) is an enzyme with systematic name GDP-mannose:D-Glc-beta-(1->4)-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase .[1][2][3][4][5] This enzyme catalyses the following chemical reaction
| GDP-mannose:cellobiosyl-diphosphopolyprenol alpha-mannosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.4.1.252 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- GDP-mannose + D-Glc-beta-(1->4)-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol GDP + D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol
In the bacterium Gluconacetobacter xylinus the enzyme is involved in the biosynthesis of the exopolysaccharide acetan.
References
edit- ^ Geremia RA, Roux M, Ferreiro DU, Dauphin-Dubois R, Lellouch AC, Ielpi L (July 1999). "Expression and biochemical characterisation of recombinant AceA, a bacterial alpha-mannosyltransferase". Molecular & General Genetics. 261 (6): 933–40. doi:10.1007/s004380051040. PMID 10485283.
- ^ Abdian PL, Lellouch AC, Gautier C, Ielpi L, Geremia RA (December 2000). "Identification of essential amino acids in the bacterial alpha -mannosyltransferase aceA". The Journal of Biological Chemistry. 275 (51): 40568–75. doi:10.1074/jbc.M007496200. hdl:11336/47751. PMID 11001941.
- ^ Petroni EA, Ielpi L (August 1996). "Isolation and nucleotide sequence of the GDP-mannose:cellobiosyl-diphosphopolyprenol alpha-mannosyltransferase gene from Acetobacter xylinum". Journal of Bacteriology. 178 (16): 4814–21. doi:10.1128/jb.178.16.4814-4821.1996. PMC 178262. PMID 8759843.
- ^ Lellouch AC, Watt GM, Geremia RA, Flitsch SL (May 2000). "Phytanyl-pyrophosphate-linked substrate for a bacterial alpha-mannosyltransferase". Biochemical and Biophysical Research Communications. 272 (1): 290–2. doi:10.1006/bbrc.2000.2771. PMID 10872841.
- ^ Katzen, F.; Ferreiro, D.U.; Oddo, C.G.; Ielmini, M.V.; Becker, A.; Puhler, A.; Ielpi, L. (1998). "Xanthomonas campestris pv. campestris gum mutants: effects on xanthan biosynthesis and plant virulence". J. Bacteriol. 180 (7): 1607–1617. PMC 107069. PMID 9537354.
External links
edit- GDP-mannose:cellobiosyl-diphosphopolyprenol+alpha-mannosyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
