GTP-binding protein GEM is a protein that in humans is encoded by the GEM gene.[5][6][7]

GEM
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGEM, KIR, GTP binding protein overexpressed in skeletal muscle
External IDsOMIM: 600164; MGI: 99844; HomoloGene: 38024; GeneCards: GEM; OMA:GEM - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_181702
NM_005261

NM_010276

RefSeq (protein)

NP_005252
NP_859053

NP_034406

Location (UCSC)Chr 8: 94.25 – 94.26 MbChr 4: 11.7 – 11.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164949Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028214Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Maguire J, Santoro T, Jensen P, Siebenlist U, Yewdell J, Kelly K (Aug 1994). "Gem: an induced, immediate early protein belonging to the Ras family". Science. 265 (5169): 241–4. Bibcode:1994Sci...265..241M. doi:10.1126/science.7912851. PMID 7912851.
  6. ^ Ward Y, Yap SF, Ravichandran V, Matsumura F, Ito M, Spinelli B, Kelly K (Apr 2002). "The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway". J Cell Biol. 157 (2): 291–302. doi:10.1083/jcb.200111026. PMC 2199248. PMID 11956230.
  7. ^ a b "Entrez Gene: GEM GTP binding protein overexpressed in skeletal muscle".

Further reading

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