GNAT3

Guanine nucleotide-binding protein G(t) subunit alpha-3, also known as gustducin alpha-3 chain, is a protein subunit that in humans is encoded by the GNAT3 gene.

GNAT3
Identifiers
Aliases	GNAT3, GDCA, G protein subunit alpha transducin 3, HG1E
External IDs	OMIM: 139395; MGI: 3588268; HomoloGene: 24284; GeneCards: GNAT3; OMA:GNAT3 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7q21.11 Start 80,458,635 bp End 80,512,064 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 A3 Start 18,167,547 bp End 18,224,832 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad tibialis anterior muscle duodenum abdominal wall mucosa of small intestine prefrontal cortex right lobe of thyroid gland left lobe of thyroid gland large intestine Top expressed in mucosa of large intestine intestinal epithelium tongue epithelium of colon mucosa of small intestine neural layer of retina vallate papilla secondary oocyte epithelium of small intestine white adipose tissue More reference expression data BioGPS n/a
Gene ontology Molecular function signal transducer activity metal ion binding nucleotide binding guanyl nucleotide binding G protein-coupled receptor binding G-protein beta/gamma-subunit complex binding GTP binding GTPase activity Cellular component acrosomal vesicle cytoplasm axoneme heterotrimeric G-protein complex apical plasma membrane plasma membrane photoreceptor outer segment photoreceptor inner segment protein-containing complex Biological process signal transduction sensory perception of umami taste response to nicotine adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway sensory perception of bitter taste sensory perception of taste sensory perception of sweet taste protein folding detection of chemical stimulus involved in sensory perception of bitter taste G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 346562 242851 Ensembl ENSG00000214415 ENSMUSG00000028777 UniProt A8MTJ3 Q3V3I2 RefSeq (mRNA) NM_001102386 NM_001081143 RefSeq (protein) NP_001095856 NP_001074612 Location (UCSC) Chr 7: 80.46 – 80.51 Mb Chr 5: 18.17 – 18.22 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Gustducin alpha-3 chain is a subunit of the heterotrimeric G protein gustducin that is responsible for basic taste.

Further reading

• Oldham WM, Van Eps N, Preininger AM, et al. (2006). "Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins". Nat. Struct. Mol. Biol. 13 (9): 772–7. doi:10.1038/nsmb1129. PMID 16892066. S2CID 290532.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Rozengurt N, Wu SV, Chen MC, et al. (2006). "Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon". Am. J. Physiol. Gastrointest. Liver Physiol. 291 (5): G792-802. doi:10.1152/ajpgi.00074.2006. PMID 16728727.
• Huang L, Shanker YG, Dubauskaite J, et al. (1999). "Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium". Nat. Neurosci. 2 (12): 1055–62. doi:10.1038/15981. PMID 10570481. S2CID 24494794.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Luttrell LM (2008). "Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors". Mol. Biotechnol. 39 (3): 239–64. doi:10.1007/s12033-008-9031-1. PMID 18240029. S2CID 45173229.
• Margolskee RF, Dyer J, Kokrashvili Z, et al. (2007). "T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1". Proc. Natl. Acad. Sci. U.S.A. 104 (38): 15075–80. Bibcode:2007PNAS..10415075M. doi:10.1073/pnas.0706678104. PMC 1986615. PMID 17724332.
• Takami S, Getchell TV, McLaughlin SK, et al. (1994). "Human taste cells express the G protein alpha-gustducin and neuron-specific enolase". Brain Res. Mol. Brain Res. 22 (1–4): 193–203. doi:10.1016/0169-328X(94)90047-7. PMID 8015379.
• Jang HJ, Kokrashvili Z, Theodorakis MJ, et al. (2007). "Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1". Proc. Natl. Acad. Sci. U.S.A. 104 (38): 15069–74. Bibcode:2007PNAS..10415069J. doi:10.1073/pnas.0706890104. PMC 1986614. PMID 17724330.
• Li X, Staszewski L, Xu H, et al. (2002). "Human receptors for sweet and umami taste". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4692–6. Bibcode:2002PNAS...99.4692L. doi:10.1073/pnas.072090199. PMC 123709. PMID 11917125.
• Fehr J, Meyer D, Widmayer P, et al. (2007). "Expression of the G-protein alpha-subunit gustducin in mammalian spermatozoa". J. Comp. Physiol. A. 193 (1): 21–34. doi:10.1007/s00359-006-0168-8. PMID 17021831. S2CID 25762931.
• Lambright DG, Noel JP, Hamm HE, Sigler PB (1994). "Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein". Nature. 369 (6482): 621–8. Bibcode:1994Natur.369..621L. doi:10.1038/369621a0. PMID 8208289. S2CID 4238569.