Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 is a protein that in humans is encoded by the GNB2 gene .[ 4] [ 5]
Heterotrimeric guanine nucleotide-binding proteins (G proteins ), which integrate signals between receptors and effector proteins , are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes.
This gene encodes a beta subunit . Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5' UTR.[ 5]
^ a b c GRCh38: Ensembl release 89: ENSG00000172354 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Glockner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (Dec 1998). "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes" . Genome Res . 8 (10): 1060–73. doi :10.1101/gr.8.10.1060 . PMC 310788 PMID 9799793 . ^ a b "Entrez Gene: GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2" .
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