GNG4

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 is a protein that in humans is encoded by the GNG4 gene.

GNG4
Identifiers
Aliases	GNG4, G protein subunit gamma 4, HG3C
External IDs	OMIM: 604388; MGI: 102703; HomoloGene: 3299; GeneCards: GNG4; OMA:GNG4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q42.3 Start 235,547,685 bp End 235,650,754 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13 A1|13 5.29 cM Start 13,958,644 bp End 14,002,481 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence islet of Langerhans ventricular zone hypothalamus amygdala left ovary pituitary gland caudate nucleus nucleus accumbens prefrontal cortex Top expressed in facial motor nucleus substantia nigra olfactory bulb lateral septal nucleus islet of Langerhans Rostral migratory stream supraoptic nucleus paraventricular nucleus of hypothalamus molar condyle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding signal transducer activity GTPase activity G-protein beta-subunit binding Cellular component plasma membrane extracellular exosome membrane heterotrimeric G-protein complex G-protein beta/gamma-subunit complex Biological process G protein-coupled receptor signaling pathway cellular response to glucagon stimulus negative regulation of cell growth regulation of G protein-coupled receptor signaling pathway signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2786 14706 Ensembl ENSG00000168243 ENSG00000282972 ENSMUSG00000021303 UniProt P50150 P50153 RefSeq (mRNA) NM_001098721 NM_001098722 NM_004485 NM_010317 NM_001302997 RefSeq (protein) NP_001092191 NP_001092192 NP_004476 NP_001289926 NP_034447 Location (UCSC) Chr 1: 235.55 – 235.65 Mb Chr 13: 13.96 – 14 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

GNG4 has been shown to sometimes interact with GNB1.{

Further reading

• Downes GB, Gautam N (1999). "The G protein subunit gene families". Genomics. 62 (3): 544–52. doi:10.1006/geno.1999.5992. PMID 10644457.
• Pumiglia KM, LeVine H, Haske T, Habib T, Jove R, Decker SJ (1995). "A direct interaction between G-protein beta gamma subunits and the Raf-1 protein kinase". J. Biol. Chem. 270 (24): 14251–4. doi:10.1074/jbc.270.24.14251. PMID 7782277.
• Yan K, Kalyanaraman V, Gautam N (1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. Chem. 271 (12): 7141–6. doi:10.1074/jbc.271.12.7141. PMID 8636150.
• Cuello F, Schulze RA, Heemeyer F, Meyer HE, Lutz S, Jakobs KH, Niroomand F, Wieland T (2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta". J. Biol. Chem. 278 (9): 7220–6. doi:10.1074/jbc.M210304200. PMID 12486123.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.