Guanine nucleotide-binding protein G(T) subunit gamma-T1 is a protein that in humans is encoded by the GNGT1 gene.[5][6] Either GNGT1 or GNGT2 is the gamma subunit (Gγ) of the Gβγ part of transducin (written G(T) or Gt), a heterotrimeric G-protein naturally expressed in vertebrate retina rod and cone cells. GNGT1 only occurs in rod cells, and GNGT2 only occurs in cone cells, with a different alpha (Gα) subunit.[7][8]

GNGT1
Identifiers
AliasesGNGT1, GNG1, G protein subunit gamma transducin 1, HG3G1
External IDsOMIM: 189970; MGI: 109165; HomoloGene: 7738; GeneCards: GNGT1; OMA:GNGT1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021955
NM_001329426

NM_010314

RefSeq (protein)

NP_001316355
NP_068774

NP_034444

Location (UCSC)Chr 7: 93.59 – 93.91 MbChr 6: 3.99 – 4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000127928Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029663Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Scherer SW, Feinstein DS, Oliveira L, Tsui LC, Pittler SJ (Sep 1996). "Gene structure and chromosome localization to 7q21.3 of the human rod photoreceptor transducin gamma-subunit gene (GNGT1)". Genomics. 35 (1): 241–3. doi:10.1006/geno.1996.0346. PMID 8661128.
  6. ^ "Entrez Gene: GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1".
  7. ^ Lagman D, Sundström G, Ocampo Daza D, Abalo XM, Larhammar D (2012). "Expansion of transducin subunit gene families in early vertebrate tetraploidizations". Genomics. 100 (4): 203–211. doi:10.1016/j.ygeno.2012.07.005. PMID 22814267.
  8. ^ Lerea CL, Somers DE, Hurley JB, Klock IB, Bunt-Milam AH (October 1986). "Identification of specific transducin alpha subunits in retinal rod and cone photoreceptors". Science. 234 (4772): 77–80. Bibcode:1986Sci...234...77L. doi:10.1126/science.3529395. PMID 3529395.

Further reading

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  • Overview of all the structural information available in the PDB for UniProt: P02698 (Bovine Guanine nucleotide-binding protein G(T) subunit gamma-T1) at the PDBe-KB.