GNPDA1

Glucosamine-6-phosphate isomerase 1 is an enzyme that in humans is encoded by the GNPDA1 gene.

GNPDA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1NE7
Identifiers
Aliases	GNPDA1, GNP1, GNPDA, GNPI, GPI, HLN, glucosamine-6-phosphate deaminase 1
External IDs	OMIM: 601798; MGI: 1347054; HomoloGene: 38054; GeneCards: GNPDA1; OMA:GNPDA1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q31.3 Start 141,991,749 bp End 142,013,041 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18|18 B3 Start 38,460,588 bp End 38,472,056 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in beta cell kidney tubule ventricular zone right adrenal cortex retinal pigment epithelium renal medulla human kidney jejunal mucosa metanephric glomerulus left adrenal gland Top expressed in yolk sac blastocyst right kidney granulocyte morula tail of embryo proximal tubule neural layer of retina muscle of thigh primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding hydrolase activity glucosamine-6-phosphate deaminase activity identical protein binding Cellular component extracellular exosome cytosol cytoplasm Biological process N-acetylglucosamine metabolic process generation of precursor metabolites and energy single fertilization glucosamine catabolic process carbohydrate metabolic process N-acetylglucosamine catabolic process UDP-N-acetylglucosamine biosynthetic process N-acetylneuraminate catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10007 26384 Ensembl ENSG00000113552 ENSMUSG00000052102 UniProt P46926 O88958 RefSeq (mRNA) NM_005471 NM_011937 RefSeq (protein) NP_005462 NP_036067 Location (UCSC) Chr 5: 141.99 – 142.01 Mb Chr 18: 38.46 – 38.47 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Weidanz JA, Campbell P, DeLucas LJ, et al. (1995). "Glucosamine 6-phosphate deaminase in normal human erythrocytes". Br. J. Haematol. 91 (1): 72–9. doi:10.1111/j.1365-2141.1995.tb05247.x. PMID 7577655. S2CID 31559803.
• Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
• Oliva G, Fontes MR, Garratt RC, et al. (1996). "Structure and catalytic mechanism of glucosamine 6-phosphate deaminase from Escherichia coli at 2.1 A resolution". Structure. 3 (12): 1323–32. doi:10.1016/S0969-2126(01)00270-2. hdl:11449/64662. PMID 8747459.
• Nakamura Y, Miura K, Fujino Y, et al. (2001). "Evolution, structure, and expression of GNPI/Oscillin orthologous genes". Genomics. 68 (2): 179–86. doi:10.1006/geno.2000.6287. PMID 10964516.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhang J, Zhang W, Zou D, et al. (2003). "Cloning and functional characterization of GNPI2, a novel human homolog of glucosamine-6-phosphate isomerase/oscillin". J. Cell. Biochem. 88 (5): 932–40. doi:10.1002/jcb.10444. PMID 12616532. S2CID 24448482.
• Arreola R, Valderrama B, Morante ML, Horjales E (2003). "Two mammalian glucosamine-6-phosphate deaminases: a structural and genetic study". FEBS Lett. 551 (1–3): 63–70. doi:10.1016/S0014-5793(03)00896-2. PMID 12965206. S2CID 45050024.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5". Nature. 431 (7006): 268–74. Bibcode:2004Natur.431..268S. doi:10.1038/nature02919. PMID 15372022.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links

• GNPDA1 human gene location in the UCSC Genome Browser.
• GNPDA1 human gene details in the UCSC Genome Browser.