Glycoprotein IX

Glycoprotein IX (platelet) (GP9) also known as CD42a (Cluster of Differentiation 42a), is a human gene.

GP9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3REZ
Identifiers
Aliases	GP9, CD42a, GPIX, Glycoprotein IX, glycoprotein IX platelet
External IDs	OMIM: 173515; MGI: 1860137; HomoloGene: 144; GeneCards: GP9; OMA:GP9 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q21.3 Start 129,060,779 bp End 129,062,406 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6 D1|6 39.13 cM Start 87,755,054 bp End 87,756,750 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte blood right lung spleen bone marrow upper lobe of left lung bone marrow cells mucosa of nose olfactory zone of nasal mucosa Top expressed in blood fetal liver hematopoietic progenitor cell tibiofemoral joint spleen embryo granulocyte morula yolk sac right lung morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process platelet activation blood coagulation, intrinsic pathway hemostasis cell adhesion blood coagulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2815 54368 Ensembl ENSG00000169704 ENSMUSG00000030054 UniProt P14770 O88186 RefSeq (mRNA) NM_000174 NM_018762 RefSeq (protein) NP_000165 NP_061232 Location (UCSC) Chr 3: 129.06 – 129.06 Mb Chr 6: 87.76 – 87.76 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Platelet glycoprotein IX (GP9) is a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib (GP Ib), a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor (VWF; MIM 193400) (known as the Glycoprotein Ib-IX-V Receptor Complex). The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with GP9 and platelet glycoprotein V (GP5; MIM 173511).[supplied by OMIM]

See also

• Cluster of differentiation

Further reading

• Kunishima S, Kamiya T, Saito H (2003). "Genetic abnormalities of Bernard-Soulier syndrome". Int. J. Hematol. 76 (4): 319–27. doi:10.1007/BF02982690. PMID 12463594. S2CID 23635810.
• Hickey MJ, Deaven LL, Roth GJ (1991). "Human platelet glycoprotein IX. Characterization of cDNA and localization of the gene to chromosome 3". FEBS Lett. 274 (1–2): 189–92. doi:10.1016/0014-5793(90)81361-Q. PMID 2253772. S2CID 12468752.
• Du X, Beutler L, Ruan C, et al. (1987). "Glycoprotein Ib and glycoprotein IX are fully complexed in the intact platelet membrane". Blood. 69 (5): 1524–7. doi:10.1182/blood.V69.5.1524.1524. PMID 2436691.
• Andrews RK, Booth WJ, Gorman JJ, et al. (1990). "Purification of botrocetin from Bothrops jararaca venom. Analysis of the botrocetin-mediated interaction between von Willebrand factor and the human platelet membrane glycoprotein Ib-IX complex". Biochemistry. 28 (21): 8317–26. doi:10.1021/bi00447a009. PMID 2557900.
• Hickey MJ, Williams SA, Roth GJ (1989). "Human platelet glycoprotein IX: an adhesive prototype of leucine-rich glycoproteins with flank-center-flank structures". Proc. Natl. Acad. Sci. U.S.A. 86 (17): 6773–7. Bibcode:1989PNAS...86.6773H. doi:10.1073/pnas.86.17.6773. PMC 297928. PMID 2771955.
• Roth GJ, Ozols J, Nugent DJ, Williams SA (1988). "Isolation and characterization of human platelet glycoprotein IX". Biochem. Biophys. Res. Commun. 156 (2): 931–9. doi:10.1016/S0006-291X(88)80933-1. PMID 3056407.
• Meyer SC, Fox JE (1995). "Interaction of platelet glycoprotein V with glycoprotein Ib-IX regulates expression of the glycoproteins and binding of von Willebrand factor to glycoprotein Ib-IX in transfected cells". J. Biol. Chem. 270 (24): 14693–9. doi:10.1074/jbc.270.24.14693. PMID 7782333.
• Clemetson JM, Kyrle PA, Brenner B, Clemetson KJ (1994). "Variant Bernard-Soulier syndrome associated with a homozygous mutation in the leucine-rich domain of glycoprotein IX". Blood. 84 (4): 1124–31. doi:10.1182/blood.V84.4.1124.1124. PMID 8049428.
• Hickey MJ, Roth GJ (1993). "Characterization of the gene encoding human platelet glycoprotein IX". J. Biol. Chem. 268 (5): 3438–43. doi:10.1016/S0021-9258(18)53713-3. PMID 8429020.
• Wright SD, Michaelides K, Johnson DJ, et al. (1993). "Double heterozygosity for mutations in the platelet glycoprotein IX gene in three siblings with Bernard-Soulier syndrome". Blood. 81 (9): 2339–47. doi:10.1182/blood.V81.9.2339.2339. PMID 8481514.
• Berger G, Massé JM, Cramer EM (1996). "Alpha-granule membrane mirrors the platelet plasma membrane and contains the glycoproteins Ib, IX, and V". Blood. 87 (4): 1385–95. doi:10.1182/blood.V87.4.1385.bloodjournal8741385. PMID 8608228.
• Hollmann C, Haag F, Schlott M, et al. (1996). "Molecular characterization of mouse T-cell ecto-ADP-ribosyltransferase Rt6: cloning of a second functional gene and identification of the Rt6 gene products". Mol. Immunol. 33 (9): 807–17. doi:10.1016/0161-5890(96)00008-9. PMID 8811076.
• Noris P, Simsek S, Stibbe J, von dem Borne AE (1997). "A phenylalanine-55 to serine amino-acid substitution in the human glycoprotein IX leucine-rich repeat is associated with Bernard-Soulier syndrome". Br. J. Haematol. 97 (2): 312–20. doi:10.1046/j.1365-2141.1997.582706.x. PMID 9163595. S2CID 19759549.
• Hayashi T, Suzuki K, Yahagi A, et al. (1997). "Corrected DNA sequence of the platelet glycoprotein IX gene". Thromb. Haemost. 77 (5): 1034–5. doi:10.1055/s-0038-1656099. PMID 9184424. S2CID 6328233.
• Bradford HN, Dela Cadena RA, Kunapuli SP, et al. (1997). "Human kininogens regulate thrombin binding to platelets through the glycoprotein Ib-IX-V complex". Blood. 90 (4): 1508–15. doi:10.1182/blood.V90.4.1508. PMID 9269768.
• Suzuki K, Hayashi T, Yahagi A, et al. (1998). "Novel point mutation in the leucine-rich motif of the platelet glycoprotein IX associated with Bernard-Soulier syndrome". Br. J. Haematol. 99 (4): 794–800. doi:10.1046/j.1365-2141.1997.4753275.x. PMID 9432024. S2CID 20513918.
• Noris P, Arbustini E, Spedini P, et al. (1999). "A new variant of Bernard-Soulier syndrome characterized by dysfunctional glycoprotein (GP) Ib and severely reduced amounts of GPIX and GPV". Br. J. Haematol. 103 (4): 1004–13. doi:10.1046/j.1365-2141.1998.01100.x. PMID 9886312. S2CID 7435503.
• Longhurst CM, White MM, Wilkinson DA, Jennings LK (1999). "A CD9, alphaIIbbeta3, integrin-associated protein, and GPIb/V/IX complex on the surface of human platelets is influenced by alphaIIbbeta3 conformational states". Eur. J. Biochem. 263 (1): 104–11. doi:10.1046/j.1432-1327.1999.00467.x. PMID 10429193.
• Kunishima S, Tomiyama Y, Honda S, et al. (2000). "Cys97→Tyr mutation in the glycoprotein IX gene associated with Bernard-Soulier syndrome". Br. J. Haematol. 107 (3): 539–45. doi:10.1046/j.1365-2141.1999.01733.x. PMID 10583255. S2CID 28086704.
• Rivera CE, Villagra J, Riordan M, et al. (2001). "Identification of a new mutation in platelet glycoprotein IX (GPIX) in a patient with Bernard-Soulier syndrome". Br. J. Haematol. 112 (1): 105–8. doi:10.1046/j.1365-2141.2001.02529.x. PMID 11167791. S2CID 887208.

External links

• GP9+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: P14770 (Platelet glycoprotein IX) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.