GPR158

GPR158
Identifiers
Aliases	GPR158, G protein-coupled receptor 158
External IDs	OMIM: 614573; MGI: 2441697; HomoloGene: 19381; GeneCards: GPR158; OMA:GPR158 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	25,602,229 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	21,835,358 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; middle temporal gyrus; ; cerebellar vermis; ; Brodmann area 23; ; lateral nuclear group of thalamus; ; Brodmann area 46; ; pons; ; superior frontal gyrus; ; postcentral gyrus; ; primary visual cortex;
	Top expressed in
	superior frontal gyrus; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; secondary oocyte; ; supraoptic nucleus; ; lumbar subsegment of spinal cord; ; neural layer of retina; ; CA3 field; ; lumbar spinal ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	G protein-coupled receptor signaling pathway; protein localization to plasma membrane; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	57512
	241263
	ENSG00000151025
	ENSMUSG00000045967
	Q5T848
	Q8C419
	NM_020752
	NM_001004761; NM_175706
	NP_065803
	NP_001004761
	Wikidata
View/Edit Human	View/Edit Mouse

Probable G-protein coupled receptor 158 (GPR158), also known as the metabotropic glycine receptor (mGlyR),^[5] is a protein that in humans is encoded by the GPR158 gene.^[6]

Function

This protein is an orphan class C GPCR. It is highly expressed in the brain, where it binds to RGS7, an inhibitor of G_i/o-coupled GPCR signaling, localizing it to the plasma membrane.^[7]

It is expressed at lower levels in other organs and shows an unusual subcellular localization pattern, being found at both the plasma membrane and in the nucleus.^[8]

Clinical significance

Role in mood regulation

GPR158 in the medial prefrontal cortex (mPFC) has been shown to regulate stress-induced depression in a mouse model of depression and has been found to be upregulated in post-mortem tissue samples from humans with major depressive disorder (MDD).^[9]

Role in prostate cancer

The GPR158 gene is an androgen-regulated gene that stimulates cell proliferation in prostate cancer cell lines, and it is linked to neuroendocrine differentiation.^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151025 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045967 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Laboute T, Zucca S, Holcomb M, Patil DN, Garza C, Wheatley BA, Roy RN, Forli S, Martemyanov KA (March 2023). "Orphan receptor GPR158 serves as a metabotropic glycine receptor: mGlyR". Science. 379 (6639): 1352–1358. Bibcode:2023Sci...379.1352L. doi:10.1126/science.add7150. PMC 10751545. PMID 36996198. S2CID 257836784.
^ "Entrez Gene: GPR158 G protein-coupled receptor 158".
^ Orlandi C, Posokhova E, Masuho I, Ray TA, Hasan N, Gregg RG, Martemyanov KA (2012). "GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes". J. Cell Biol. 197 (6): 711–9. doi:10.1083/jcb.201202123. PMC 3373406. PMID 22689652.
^ Patel N, Itakura T, Gonzalez JM, Schwartz SG, Fini ME (2013). "GPR158, an orphan member of G protein-coupled receptor Family C: glucocorticoid-stimulated expression and novel nuclear role". PLOS ONE. 8 (2): e57843. Bibcode:2013PLoSO...857843P. doi:10.1371/journal.pone.0057843. PMC 3581496. PMID 23451275.
^ Sutton L, Orlandi C, Song C, Oh WC, Muntean BS, Xie K, Filippini A, Xie X, Satterfield R, Yaeger JD, Renner KJ, Young Jr SM, Xu B, Kwon H, Martemyanov KA (2018). "Orphan receptor GPR158 controls stress-induced depression". eLife. 7. doi:10.7554/eLife.33273.001. PMC 5823542. PMID 29419376.
^ Patel N, Itakura T, Jeong S, Liao CP, Roy-Burman P, Zandi E, Groshen S, Pinski J, Coetzee GA, Gross ME, Fini ME (2015). "Expression and functional role of orphan receptor GPR158 in prostate cancer growth and progression". PLOS ONE. 10 (2): e0117758. Bibcode:2015PLoSO..1017758P. doi:10.1371/journal.pone.0117758. PMC 4333349. PMID 25693195.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000151025 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000045967 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid36996198-5] Laboute T, Zucca S, Holcomb M, Patil DN, Garza C, Wheatley BA, Roy RN, Forli S, Martemyanov KA (March 2023). "Orphan receptor GPR158 serves as a metabotropic glycine receptor: mGlyR". Science. 379 (6639): 1352–1358. Bibcode:2023Sci...379.1352L. doi:10.1126/science.add7150. PMC 10751545. PMID 36996198. S2CID 257836784.

[entrez-6] "Entrez Gene: GPR158 G protein-coupled receptor 158".

[pmid22689652-7] Orlandi C, Posokhova E, Masuho I, Ray TA, Hasan N, Gregg RG, Martemyanov KA (2012). "GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes". J. Cell Biol. 197 (6): 711–9. doi:10.1083/jcb.201202123. PMC 3373406. PMID 22689652.

[pmid23451275-8] Patel N, Itakura T, Gonzalez JM, Schwartz SG, Fini ME (2013). "GPR158, an orphan member of G protein-coupled receptor Family C: glucocorticoid-stimulated expression and novel nuclear role". PLOS ONE. 8 (2): e57843. Bibcode:2013PLoSO...857843P. doi:10.1371/journal.pone.0057843. PMC 3581496. PMID 23451275.

[9] Sutton L, Orlandi C, Song C, Oh WC, Muntean BS, Xie K, Filippini A, Xie X, Satterfield R, Yaeger JD, Renner KJ, Young Jr SM, Xu B, Kwon H, Martemyanov KA (2018). "Orphan receptor GPR158 controls stress-induced depression". eLife. 7. doi:10.7554/eLife.33273.001. PMC 5823542. PMID 29419376.

[pmid25693195-10] Patel N, Itakura T, Jeong S, Liao CP, Roy-Burman P, Zandi E, Groshen S, Pinski J, Coetzee GA, Gross ME, Fini ME (2015). "Expression and functional role of orphan receptor GPR158 in prostate cancer growth and progression". PLOS ONE. 10 (2): e0117758. Bibcode:2015PLoSO..1017758P. doi:10.1371/journal.pone.0117758. PMC 4333349. PMID 25693195.

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