Gasdermin B is a protein that in humans is encoded by the GSDMB gene. [3]

GSDMB
Identifiers
AliasesGSDMB, GSDML, PRO2521, PP4052, gasdermin B, GSDMB-1
External IDsOMIM: 611221; HomoloGene: 88856; GeneCards: GSDMB; OMA:GSDMB - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001042471
NM_001165958
NM_001165959
NM_018530
NM_001369402

n/a

RefSeq (protein)

NP_001035936
NP_001159430
NP_001159431
NP_061000
NP_001356331

n/a

Location (UCSC)Chr 17: 39.9 – 39.92 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Function

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This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding.

Clinical significance

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GSDMB expression has been linked to higher survival rates for lung cancer patients.[4]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000073605Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Entrez Gene: Gasdermin B". Retrieved 2016-08-26.
  4. ^ "MCM team has been researching GSDMB". World Community Grid. 12 July 2023. Retrieved 20 September 2024.

Further reading

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  • Katoh M, Katoh M (2004). "Evolutionary recombination hotspot around GSDML-GSDM locus is closely linked to the oncogenomic recombination hotspot around the PPP1R1B-ERBB2-GRB7 amplicon". Int. J. Oncol. 24 (4): 757–63. doi:10.3892/ijo.24.4.757. PMID 15010812.


This article incorporates text from the United States National Library of Medicine, which is in the public domain.