GTF2F2

General transcription factor IIF subunit 2 is a protein that in humans is encoded by the GTF2F2 gene.

GTF2F2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BBY, 1F3U, 2BBY, 5IY9, 5IYA, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6
Identifiers
Aliases	GTF2F2, BTF4, RAP30, TF2F2, TFIIF, general transcription factor IIF subunit 2
External IDs	OMIM: 189969; MGI: 1915955; HomoloGene: 37884; GeneCards: GTF2F2; OMA:GTF2F2 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) Band 13q14.12-q14.13 Start 45,120,510 bp End 45,284,893 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 D3 Start 76,134,377 bp End 76,248,305 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad ventricular zone ganglionic eminence Achilles tendon muscle of thigh skin of abdomen testicle skin of leg Skeletal muscle tissue of biceps brachii gastrocnemius muscle Top expressed in embryo morula morula epiblast embryo uterus lens zygote spermatid cervix More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding nucleotide binding helicase activity protein binding hydrolase activity ATP binding Cellular component microtubule cytoskeleton nucleoplasm transcription factor TFIIF complex nucleus transcription preinitiation complex Biological process mRNA splicing, via spliceosome regulation of transcription, DNA-templated transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping transcription by RNA polymerase II positive regulation of transcription initiation from RNA polymerase II promoter transcription, DNA-templated positive regulation of viral transcription transcription initiation from RNA polymerase II promoter snRNA transcription by RNA polymerase II fibroblast growth factor receptor signaling pathway positive regulation of transcription elongation from RNA polymerase II promoter RNA metabolic process positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2963 68705 Ensembl ENSG00000188342 ENSMUSG00000067995 UniProt P13984 Q8R0A0 RefSeq (mRNA) NM_004128 NM_026816 RefSeq (protein) NP_004119 NP_081092 Location (UCSC) Chr 13: 45.12 – 45.28 Mb Chr 14: 76.13 – 76.25 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

GTF2F2 has been shown to interact with POLR2E and HTATSF1.

See also

• Transcription Factor II F

Further reading

• Kato H, Sumimoto H, Pognonec P, Chen CH, Rosen CA, Roeder RG (1992). "HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors". Genes Dev. 6 (4): 655–66. doi:10.1101/gad.6.4.655. PMID 1559613.
• Horikoshi M, Fujita H, Wang J, Takada R, Roeder RG (1991). "Nucleotide and amino acid sequence of RAP30". Nucleic Acids Res. 19 (19): 5436. doi:10.1093/nar/19.19.5436. PMC 328912. PMID 1840667.
• Sopta M, Burton ZF, Greenblatt J (1989). "Structure and associated DNA-helicase activity of a general transcription initiation factor that binds to RNA polymerase II". Nature. 341 (6241): 410–4. Bibcode:1989Natur.341..410S. doi:10.1038/341410a0. PMID 2477704. S2CID 4321793.
• Sopta M, Carthew RW, Greenblatt J (1985). "Isolation of three proteins that bind to mammalian RNA polymerase II". J. Biol. Chem. 260 (18): 10353–60. doi:10.1016/S0021-9258(17)39255-4. PMID 3860504.
• Tan S, Aso T, Conaway RC, Conaway JW (1994). "Roles for both the RAP30 and RAP74 subunits of transcription factor IIF in transcription initiation and elongation by RNA polymerase II". J. Biol. Chem. 269 (41): 25684–91. doi:10.1016/S0021-9258(18)47303-6. PMID 7929273.
• Yonaha M, Aso T, Kobayashi Y, Vasavada H, Yasukochi Y, Weissman SM, Kitajima S (1993). "Domain structure of a human general transcription initiation factor, TFIIF". Nucleic Acids Res. 21 (2): 273–9. doi:10.1093/nar/21.2.273. PMC 309103. PMID 8441635.
• Tang H, Sun X, Reinberg D, Ebright RH (1996). "Protein-protein interactions in eukaryotic transcription initiation: structure of the preinitiation complex". Proc. Natl. Acad. Sci. U.S.A. 93 (3): 1119–24. Bibcode:1996PNAS...93.1119T. doi:10.1073/pnas.93.3.1119. PMC 40041. PMID 8577725.
• Martin ML, Lieberman PM, Curran T (1996). "Fos-Jun dimerization promotes interaction of the basic region with TFIIE-34 and TFIIF". Mol. Cell. Biol. 16 (5): 2110–8. doi:10.1128/mcb.16.5.2110. PMC 231198. PMID 8628277.
• Fang SM, Burton ZF (1996). "RNA polymerase II-associated protein (RAP) 74 binds transcription factor (TF) IIB and blocks TFIIB-RAP30 binding". J. Biol. Chem. 271 (20): 11703–9. doi:10.1074/jbc.271.20.11703. PMID 8662660.
• Dubrovskaya V, Lavigne AC, Davidson I, Acker J, Staub A, Tora L (1996). "Distinct domains of hTAFII100 are required for functional interaction with transcription factor TFIIF beta (RAP30) and incorporation into the TFIID complex". EMBO J. 15 (14): 3702–12. doi:10.1002/j.1460-2075.1996.tb00740.x. PMC 452026. PMID 8758937.
• Rowlands JC, McEwan IJ, Gustafsson JA (1996). "Trans-activation by the human aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins: direct interactions with basal transcription factors". Mol. Pharmacol. 50 (3): 538–48. PMID 8794892.
• Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–10. Bibcode:1996Sci...274..605Z. doi:10.1126/science.274.5287.605. PMID 8849451. S2CID 13266489.
• Parada CA, Roeder RG (1996). "Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain". Nature. 384 (6607): 375–8. Bibcode:1996Natur.384..375P. doi:10.1038/384375a0. PMID 8934526. S2CID 4278432.
• Kojima S, Kobayashi A, Gotoh O, Ohkuma Y, Fujii-Kuriyama Y, Sogawa K (1997). "Transcriptional activation domain of human BTEB2, a GC box-binding factor". J. Biochem. 121 (2): 389–96. doi:10.1093/oxfordjournals.jbchem.a021600. PMID 9089417.
• Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme". Mol. Cell. Biol. 17 (4): 1817–23. doi:10.1128/mcb.17.4.1817. PMC 232028. PMID 9121429.
• McEwan IJ, Gustafsson J (1997). "Interaction of the human androgen receptor transactivation function with the general transcription factor TFIIF". Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8485–90. Bibcode:1997PNAS...94.8485M. doi:10.1073/pnas.94.16.8485. PMC 22967. PMID 9238003.
• Newberry EP, Latifi T, Battaile JT, Towler DA (1997). "Structure-function analysis of Msx2-mediated transcriptional suppression". Biochemistry. 36 (34): 10451–62. doi:10.1021/bi971008x. PMID 9265625.
• Liang G, Hai T (1997). "Characterization of human activating transcription factor 4, a transcriptional activator that interacts with multiple domains of cAMP-responsive element-binding protein (CREB)-binding protein". J. Biol. Chem. 272 (38): 24088–95. doi:10.1074/jbc.272.38.24088. PMID 9295363.
• Okamoto T, Yamamoto S, Watanabe Y, Ohta T, Hanaoka F, Roeder RG, Ohkuma Y (1998). "Analysis of the role of TFIIE in transcriptional regulation through structure-function studies of the TFIIEbeta subunit". J. Biol. Chem. 273 (31): 19866–76. doi:10.1074/jbc.273.31.19866. PMID 9677423.

External links

• GTF2F2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.