Guanylate cyclase soluble subunit alpha-3 is an enzyme that in humans is encoded by the GUCY1A3 gene.[5][6]

GUCY1A1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGUCY1A1, MYMY6, GC-SA3, GUCY1A3, GUCSA3, guanylate cyclase 1 soluble subunit alpha, guanylate cyclase 1 soluble subunit alpha 1, guanylate cyclase 1, soluble, alpha 3, GUC1A3, GUCA3
External IDsOMIM: 139396; MGI: 1926562; HomoloGene: 37360; GeneCards: GUCY1A1; OMA:GUCY1A1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021896
NM_001356987
NM_001356988

RefSeq (protein)

NP_068696
NP_001343916
NP_001343917

Location (UCSC)Chr 4: 155.67 – 155.73 MbChr 3: 82 – 82.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.[6] Mutations in this gene have been associated to cases of myocardial infarction (10.1038/nature12722).

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164116Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033910Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Giuili G, Scholl U, Bulle F, Guellaen G (Jul 1992). "Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain". FEBS Lett. 304 (1): 83–8. doi:10.1016/0014-5793(92)80594-7. PMID 1352257. S2CID 26032197.
  6. ^ a b "Entrez Gene: GUCY1A3 guanylate cyclase 1, soluble, alpha 3".

Further reading

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