GZMH

Granzyme H is a protein that in humans is encoded by the GZMH gene.

GZMH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3TJU, 3TJV, 3TK9, 4GAW
Identifiers
Aliases	GZMH, CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2, granzyme H
External IDs	OMIM: 116831; MGI: 109254; HomoloGene: 133275; GeneCards: GZMH; OMA:GZMH - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q12 Start 24,606,480 bp End 24,609,699 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14 C3|14 28.19 cM Start 56,442,720 bp End 56,448,874 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood spleen bone marrow cells periodontal fiber decidua gallbladder lymph node right lung palpebral conjunctiva Top expressed in gastrula decidua ankle joint central gray substance of midbrain nucleus of stria terminalis uterus yolk sac tail of embryo adipose tissue dentate gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity serine-type peptidase activity serine-type endopeptidase activity hydrolase activity Cellular component membrane secretory granule cytoplasm Biological process cytolysis apoptotic process proteolysis granzyme-mediated apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2999 14943 Ensembl ENSG00000100450 ENSMUSG00000015441 UniProt P20718 P08883 RefSeq (mRNA) NM_001270780 NM_001270781 NM_033423 NM_010374 RefSeq (protein) NP_001257709 NP_001257710 NP_219491 NP_034504 Location (UCSC) Chr 14: 24.61 – 24.61 Mb Chr 14: 56.44 – 56.45 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Waterhouse NJ, Trapani JA (2007). "H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells". Trends Immunol. 28 (9): 373–5. doi:10.1016/j.it.2007.08.001. PMID 17766182.
• Llorens C, Martres MP, Baudry M, Schwartz JC (1978). "Hypersensitivity to noradrenaline in cortex after chronic morphine: relevance to tolerance and dependence". Nature. 274 (5671): 603–5. Bibcode:1978Natur.274..603L. doi:10.1038/274603a0. PMID 209336. S2CID 4293645.
• Heusel JW, Hanson RD, Silverman GA, Ley TJ (1991). "Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2". J. Biol. Chem. 266 (10): 6152–8. doi:10.1016/S0021-9258(18)38097-9. PMID 2007574.
• Meier M, Kwong PC, Frégeau CJ, et al. (1990). "Cloning of a gene that encodes a new member of the human cytotoxic cell protease family". Biochemistry. 29 (17): 4042–9. doi:10.1021/bi00469a003. PMID 2193684.
• Hanson RD, Hohn PA, Popescu NC, Ley TJ (1990). "A cluster of hematopoietic serine protease genes is found on the same chromosomal band as the human alpha/delta T-cell receptor locus". Proc. Natl. Acad. Sci. U.S.A. 87 (3): 960–3. Bibcode:1990PNAS...87..960H. doi:10.1073/pnas.87.3.960. PMC 53389. PMID 2300587.
• Klein JL, Selvakumar A, Trapani JA, Dupont B (1990). "Characterization of a novel, human cytotoxic lymphocyte-specific serine protease cDNA clone (CSP-C)". Tissue Antigens. 35 (5): 220–8. doi:10.1111/j.1399-0039.1990.tb01787.x. PMID 2402757.
• MacIvor DM, Pham CT, Ley TJ (1999). "The 5' flanking region of the human granzyme H gene directs expression to T/natural killer cell progenitors and lymphokine-activated killer cells in transgenic mice". Blood. 93 (3): 963–73. doi:10.1182/blood.V93.3.963. PMID 9920846.
• Edwards KM, Kam CM, Powers JC, Trapani JA (1999). "The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes". J. Biol. Chem. 274 (43): 30468–73. doi:10.1074/jbc.274.43.30468. PMID 10521426.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Johnson H, Scorrano L, Korsmeyer SJ, Ley TJ (2003). "Cell death induced by granzyme C". Blood. 101 (8): 3093–101. doi:10.1182/blood-2002-08-2485. PMID 12515723.
• Sedelies KA, Sayers TJ, Edwards KM, et al. (2004). "Discordant regulation of granzyme H and granzyme B expression in human lymphocytes". J. Biol. Chem. 279 (25): 26581–7. doi:10.1074/jbc.M312481200. PMID 15069086.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andrade F, Fellows E, Jenne DE, et al. (2007). "Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition". EMBO J. 26 (8): 2148–57. doi:10.1038/sj.emboj.7601650. PMC 1852776. PMID 17363894.
• Fellows E, Gil-Parrado S, Jenne DE, Kurschus FC (2007). "Natural killer cell-derived human granzyme H induces an alternative, caspase-independent cell-death program". Blood. 110 (2): 544–52. doi:10.1182/blood-2006-10-051649. PMID 17409270.