In enzymology, a galactoside 2-alpha-L-fucosyltransferase (EC 2.4.1.69) is an enzyme that catalyzes the chemical reaction
| galactoside 2-alpha-L-fucosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.4.1.69 | ||||||||
| CAS no. | 56093-23-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- GDP-beta-L-fucose + beta-D-galactosyl-R GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R
Thus, the two substrates of this enzyme are GDP-beta-L-fucose and beta-D-galactosyl-R, whereas its two products are GDP and alpha-L-fucosyl-1,2-beta-D-galactosyl-R.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. This enzyme participates in 4 metabolic pathways: glycosphingolipid biosynthesis - lactoseries, glycosphingolipid biosynthesis - neo-lactoseries, glycosphingolipid biosynthesis - globoseries, and glycan structures - biosynthesis 2.
Nomenclature
editThe systematic name of this enzyme class is:
- GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase
Other names in common use include:
- blood group H alpha-2-fucosyltransferase
- guanosine diphosphofucose-galactoside 2-L-fucosyltransferase
- alpha-(1->2)-L-fucosyltransferase
- alpha-2-fucosyltransferase
- alpha-2-L-fucosyltransferase
- blood-group substance H-dependent fucosyltransferase
- guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase
- guanosine diphosphofucose-lactose fucosyltransferase
- GDP fucose-lactose fucosyltransferase
- guanosine diphospho-L-fucose-lactose fucosyltransferase
- guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase
- guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide
- alpha-L-fucosyltransferase, guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase
- H-gene-encoded beta-galactoside alpha1->2fucosyltransferase
- secretor-type beta-galactoside alpha1->2fucosyltransferase
- beta-galactoside alpha1->2fucosyltransferase
- GDP-L-fucose:lactose fucosyltransferase
References
edit- Basu S, Basu M, Chien JL (1975). "Enzymatic synthesis of a blood group H-related glycosphingolipid by an alpha-fucosyltransferase from bovine spleen". J. Biol. Chem. 250 (8): 2956–62. doi:10.1016/S0021-9258(19)41579-2. PMID 804484.
- Beyer TA, Hill RL (1980). "Enzymatic properties of the beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland". J. Biol. Chem. 255 (11): 5373–9. doi:10.1016/S0021-9258(19)70796-0. PMID 7372640.
- Beyer TA, Sadler JE, Hill RL (1980). "Purification to homogeneity of H blood group beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland". J. Biol. Chem. 255 (11): 5364–72. doi:10.1016/S0021-9258(19)70795-9. PMID 6246105.
- Grollman AP (1966). "GDP-l-fucose: Lactose fucosyltransferase from mammary gland". GDP-L-fucose:lactose fucosyltransferase from mammary gland. Methods Enzymol. Vol. 8. pp. 351–353. doi:10.1016/0076-6879(66)08065-0. ISBN 978-0-12-181808-1.
