The Gammaretrovirus core encapsidation signal is an RNA element known to be essential for stable dimerisation and efficient genome packaging during virus assembly.[1] Dimerisation of the viral RNA genomes is proposed to act as an RNA conformational switch which exposes conserved UCUG elements and enables efficient genome encapsidation.[2] The structure of this element is composed of three stem-loops. Two of the stem-loops called SL-C and SL-D form a single co-axial extend helix.
| Gammaretrovirus core encapsidation signal | |
|---|---|
 Predicted secondary structure and sequence conservation of Gammaretro_CES | |
| Identifiers | |
| Symbol | Gammaretro_CES |
| Rfam | RF00374 |
| Other data | |
| RNA type | Cis-reg |
| Domain(s) | Eukaryota; Viruses |
| SO | SO:0000233 |
| PDB structures | PDBe |
See also
editReferences
edit- ^ a b D'Souza V, Dey A, Habib D, Summers MF (2004). "NMR structure of the 101-nucleotide core encapsidation signal of the Moloney murine leukemia virus". J Mol Biol. 337 (2): 427–442. doi:10.1016/j.jmb.2004.01.037. PMID 15003457.
- ^ a b D'Souza V, Summers MF (2004). "Structural basis for packaging the dimeric genome of Moloney murine leukaemia virus". Nature. 431 (7008): 586–590. Bibcode:2004Natur.431..586D. doi:10.1038/nature02944. PMID 15457265. S2CID 4409362.
External links
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