A gangliocytic paraganglioma is a rare tumour that is typically found in the duodenum and consists of three components: (1) ganglion cells, (2) epithelioid cells (paraganglioma-like) and, (3) spindle cells (schwannoma-like).[1]
| Gangliocytic paraganglioma | |
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| Micrograph of a gangliocytic paraganglioma. H&E stain. | |
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| Specialty | Pathology |
Symptoms and signs
editThe most common presentation is gastrointestinal bleed (~45% of cases), followed by abdominal pain (~43% of cases) and anemia (~15% of cases).[2]
Pathology
editGP consist of three components (1) ganglion cells, (2) epithelioid cells (neuroendocrine-like), and (3) spindle cells (schwannoma-like). The microscopic differential diagnosis includes poorly differentiated carcinoma, neuroendocrine tumour and paraganglioma.[1]
GPs may be sporadic or arise in the context neurofibromatosis type 1.
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See also
editReferences
edit- ^ a b Wong, A.; Miller, AR.; Metter, J.; Thomas, CR. (Mar 2005). "Locally advanced duodenal gangliocytic paraganglioma treated with adjuvant radiation therapy: case report and review of the literature". World J Surg Oncol. 3 (1): 15. doi:10.1186/1477-7819-3-15. PMC 554089. PMID 15740625.
- ^ Okubo, Y.; Wakayama, M.; Nemoto, T.; Kitahara, K.; Nakayama, H.; Shibuya, K.; Yokose, T.; Yamada, M.; Shimodaira, K.; Sasai, Daisuke; Ishiwatari, Takao; Tsuchiya, Masaru; Hiruta, Nobuyuki (2011). "Literature survey on epidemiology and pathology of gangliocytic paraganglioma". BMC Cancer. 11: 187. doi:10.1186/1471-2407-11-187. PMC 3141762. PMID 21599949.