In enzymology, a gentamicin 3'-N-acetyltransferase (EC 2.3.1.60) is an enzyme that catalyzes the chemical reaction
| gentamicin 3'-N-acetyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.3.1.60 | ||||||||
| CAS no. | 58500-58-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- acetyl-CoA + gentamicin C CoA + N3'-acetylgentamicin C
Thus, the two substrates of this enzyme are acetyl-CoA and gentamicin C, whereas its two products are CoA and N3'-acetylgentamicin C.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:gentamicin-C N3'-acetyltransferase. Other names in common use include gentamicin acetyltransferase I, aminoglycoside acetyltransferase AAC(3)-1, gentamicin 3'-N-acetyltransferase, and acetyl-CoA:gentamicin-C N3'-acetyltransferase.
References
edit- Angelatou F, Litsas SB, Kontomichalou P (February 1982). "Purification and properties of two gentamicin-modifying enzymes, coded by a single plasmid pPK237 originating from Pseudomonas aeruginosa". J. Antibiot. 35 (2): 235–44. doi:10.7164/antibiotics.35.235. PMID 6281224.
- Biddlecome S, Haas M, Davies J, Miller GH, Rane DF, Daniels PJ (1976). "Enzymatic modification of aminoglycoside antibiotics: a new 3-N-acetylating enzyme from a Pseudomonas aeruginosa isolate". Antimicrob. Agents Chemother. 9 (6): 951–5. doi:10.1128/aac.9.6.951. PMC 429656. PMID 820250.
- Williams JW, Northrop DB (1976). "Purification and properties of gentamicin acetyltransferase I". Biochemistry. 15 (1): 125–31. doi:10.1021/bi00646a019. PMID 764855.
