George Lyons may refer to:
- George Lyons (theologian) (born 1947), American author and professor of New Testament studies
- George Lyons (footballer) (1884–?), English footballer
- George Lyons (baseball) (1891–1981), American professional baseball pitcher
- George Lyons (born Dominick George Martoccio; 1889–1958), American musician, harpist and composer, part of Lyons and Yosco