George Milligan may refer to:
- George Milligan (physician) (?-1799), American surgeon
- George Milligan (moderator) (1860–1934), Scottish minister of the Church of Scotland
- George Milligan (politician) (born 1934), American politician in the state of Iowa
- George Milligan (footballer) (1891–?), Scottish footballer
- George Milligan (Biblical scholar) (1860–1934), professor at Warwick University