Geranylfarnesyl diphosphate synthase (EC 2.5.1.81, FGPP synthase, (all-E) geranylfarnesyl diphosphate synthase, GFPS, Fgs) is an enzyme with systematic name geranylgeranyl-diphosphate:isopentenyl-diphosphate transtransferase (adding 1 isopentenyl unit).[1][2][3][4] This enzyme catalyses the following chemical reaction
| Geranylfarnesyl diphosphate synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.5.1.81 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- geranylgeranyl diphosphate + isopentenyl diphosphate (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
The enzyme from Methanosarcina mazei is involved in biosynthesis of the polyprenyl side-chain of methanophenazine.
References
edit- ^ Ogawa T, Yoshimura T, Hemmi H (February 2010). "Geranylfarnesyl diphosphate synthase from Methanosarcina mazei: Different role, different evolution". Biochemical and Biophysical Research Communications. 393 (1): 16–20. doi:10.1016/j.bbrc.2010.01.063. PMID 20097171.
- ^ Tachibana A, Yano Y, Otani S, Nomura N, Sako Y, Taniguchi M (January 2000). "Novel prenyltransferase gene encoding farnesylgeranyl diphosphate synthase from a hyperthermophilic archaeon, Aeropyrum pernix. Molecularevolution with alteration in product specificity". European Journal of Biochemistry. 267 (2): 321–8. doi:10.1046/j.1432-1327.2000.00967.x. PMID 10632701.
- ^ Tachibana A (March 1994). "A novel prenyltransferase, farnesylgeranyl diphosphate synthase, from the haloalkaliphilic archaeon, Natronobacterium pharaonis". FEBS Letters. 341 (2–3): 291–4. doi:10.1016/0014-5793(94)80475-3. PMID 8137956.
- ^ Lee PC, Mijts BN, Petri R, Watts KT, Schmidt-Dannert C (November 2004). "Alteration of product specificity of Aeropyrum pernix farnesylgeranyl diphosphate synthase (Fgs) by directed evolution". Protein Engineering, Design & Selection. 17 (11): 771–7. doi:10.1093/protein/gzh089. PMID 15548566.
External links
edit- Geranylfarnesyl+diphosphate+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
