Geranylgeranylglycerol-phosphate geranylgeranyltransferase

In enzymology, a geranylgeranylglycerol-phosphate geranylgeranyltransferase (EC 2.5.1.42) is an enzyme that catalyzes the chemical reaction

geranylgeranylglycerol-phosphate geranylgeranyltransferase
Identifiers
EC no.2.5.1.42
CAS no.124650-68-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins
geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate diphosphate + 2,3-bis-O-(geranylgeranyl)glycerol 1-phosphate

Thus, the two substrates of this enzyme are geranylgeranyl diphosphate and sn-3-O-(geranylgeranyl)glycerol 1-phosphate, whereas its two products are diphosphate and 2,3-bis-O-(geranylgeranyl)glycerol 1-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring aryl groups or alkyl groups other than methyl groups. The systematic name of this enzyme class is geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase. Other names in common use include geranylgeranyloxyglycerol phosphate geranylgeranyltransferase, and geranylgeranyltransferase II.

Structural studies

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As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2F6U and 2F6X.

References

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  • Zhang DL, Daniels L, Poulter CD (1990). "Biosynthesis of archaebacterial membranes. Formation of isoprene ethers by a prenyl transfer reaction". J. Am. Chem. Soc. 112 (3): 1264–1265. doi:10.1021/ja00159a067.