Gigliola is a feminine Italian given name. Notable people with the name include:
- Gigliola Cinquetti (born 1947), Italian singer and television presenter
- Gigliola Frazzoni (1923–2016), Italian opera singer
- Gigliola Staffilani (born 1966), American mathematician
- Gigliola da Carrara (1379–1416), Marchioness of Ferrara