Gillian Griffiths is a British cell biologist and immunologist. Griffiths was one of the first to show that immune cells have specialised mechanisms of secretion, and identified proteins and mechanisms that control cytotoxic T lymphocyte secretion.[1] Griffiths is Professor of Cell Biology and Immunology at the University of Cambridge and is the Director of the Cambridge Institute for Medical Research.[1][2][3][4][5][6]
Gillian Griffiths | |
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| Born | Gillian M. Griffiths |
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| Scientific career | |
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| Thesis | Molecular analysis of the immune response (1983) |
| Doctoral advisor | César Milstein |
| Website | med |
Education
editWhen she was young, Griffiths initially thought she might like to be an ecologist. However, she began her scientific career at University College London by studying immunology. She continued in the subject, undertaking her PhD at the MRC Laboratory of Molecular Biology in Cambridge supervised by César Milstein.[7]
Awards and honours
editGriffiths holds a Wellcome Trust Principal Research Fellowship and she is a Fellow at King's College, Cambridge. Griffiths was elected a Fellow of the Royal Society in 2013. Her nomination for the Royal Society reads
Gillian Griffiths has made key contributions to the fields of both cell biology and immunology, introducing important new concepts into both fields. Gillian Griffiths was one of the first to show that immune cells used specialised mechanisms of secretion, identifying the proteins and mechanisms controlling secretion from cytotoxic T lymphocytes by studying human genetic diseases and biochemical approaches. Her work has identified a new and unexpected role for the centrosome in exocytosis, and revealed that centrosome docking at the plasma membrane provides a focal point for exocytosis and endocytosis. Her work is both elegant and insightful.[1]
- 2019: Awarded the Buchanan Medal of the Royal Society.[8]
References
edit- ^ a b c "Professor Gillian Griffiths FMedSci FRS". The Royal Society. Archived from the original on 20 June 2019. Retrieved 11 October 2013.
- ^ Stinchcombe, J. C.; Salio, M; Cerundolo, V; Pende, D; Arico, M; Griffiths, G. M. (2011). "Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems". BMC Biology. 9: 45. doi:10.1186/1741-7007-9-45. PMC 3149597. PMID 21711522.
- ^ Tsun, A; Qureshi, I; Stinchcombe, J. C.; Jenkins, M. R.; de la Roche, M; Kleczkowska, J; Zamoyska, R; Griffiths, G. M. (2011). "Centrosome docking at the immunological synapse is controlled by Lck signaling". The Journal of Cell Biology. 192 (4): 663–74. doi:10.1083/jcb.201008140. PMC 3044125. PMID 21339332.
- ^ Griffiths, G. M.; Tsun, A.; Stinchcombe, J. C. (2010). "The immunological synapse: A focal point for endocytosis and exocytosis". The Journal of Cell Biology. 189 (3): 399–406. doi:10.1083/jcb.201002027. PMC 2867296. PMID 20439993.
- ^ Cetica, V; Santoro, A; Gilmour, K. C.; Sieni, E; Beutel, K; Pende, D; Marcenaro, S; Koch, F; Grieve, S; Wheeler, R; Zhao, F; Zur Stadt, U; Griffiths, G. M.; Aricò, M (2010). "STXBP2 mutations in children with familial haemophagocytic lymphohistiocytosis type 5". Journal of Medical Genetics. 47 (9): 595–600. doi:10.1136/jmg.2009.075341. PMC 4115259. PMID 20798128.
- ^ Gillian Griffiths's publications indexed by the Scopus bibliographic database. (subscription required)
- ^ Sedwick, C. (2013). "Gillian Griffiths: How T cells get on target". The Journal of Cell Biology. 200 (1): 4–5. doi:10.1083/jcb.2001pi. PMC 3542799. PMID 23295346.
- ^ "Buchanan Medallist 2019". Royal Society. Retrieved 5 October 2019.