Glucose-6-phosphate dehydrogenase (coenzyme-F420) (EC 1.1.98.2, coenzyme F420-dependent glucose-6-phosphate dehydrogenase, F420-dependent glucose-6-phosphate dehydrogenase, FGD1, Rv0407, F420-dependent glucose-6-phosphate dehydrogenase 1) is an enzyme with systematic name D-glucose-6-phosphate:F420 1-oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction
| Glucose-6-phosphate dehydrogenase (coenzyme-F420) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.98.2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- D-glucose 6-phosphate + oxidized coenzyme F420 6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420
Thus enzyme is specific for D-glucose 6-phosphate.
References
edit- ^ Purwantini E, Daniels L (May 1996). "Purification of a novel coenzyme F420-dependent glucose-6-phosphate dehydrogenase from Mycobacterium smegmatis". Journal of Bacteriology. 178 (10): 2861–6. PMC 178021. PMID 8631674.
- ^ Bashiri G, Squire CJ, Baker EN, Moreland NJ (July 2007). "Expression, purification and crystallization of native and selenomethionine labeled Mycobacterium tuberculosis FGD1 (Rv0407) using a Mycobacterium smegmatis expression system". Protein Expression and Purification. 54 (1): 38–44. doi:10.1016/j.pep.2007.01.014. PMID 17376702.
- ^ Purwantini E, Gillis TP, Daniels L (January 1997). "Presence of F420-dependent glucose-6-phosphate dehydrogenase in Mycobacterium and Nocardia species, but absence from Streptomyces and Corynebacterium species and methanogenic Archaea". FEMS Microbiology Letters. 146 (1): 129–34. doi:10.1111/j.1574-6968.1997.tb10182.x. PMID 8997717.
External links
edit- Glucose-6-phosphate+dehydrogenase+(coenzyme-F420) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
