Glucosyl-3-phosphoglycerate synthase (EC 2.4.1.266, GpgS protein, GPG synthase, glucosylphosphoglycerate synthase) is an enzyme with systematic name NDP-glucose:3-phospho-D-glycerate 2-alpha-D-glucosyltransferase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
| Glucosyl-3-phosphoglycerate synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.4.1.266 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- NDP-glucose + 3-phospho-D-glycerate NDP + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate
The enzyme is involved in biosynthesis of 2-O-(alpha-D-glucopyranosyl)-D-glycerate.
References
edit- ^ Costa J, Empadinhas N, da Costa MS (March 2007). "Glucosylglycerate biosynthesis in the deepest lineage of the Bacteria: characterization of the thermophilic proteins GpgS and GpgP from Persephonella marina". Journal of Bacteriology. 189 (5): 1648–54. doi:10.1128/JB.00841-06. PMC 1855766. PMID 17189358.
- ^ Costa J, Empadinhas N, Gonçalves L, Lamosa P, Santos H, da Costa MS (February 2006). "Characterization of the biosynthetic pathway of glucosylglycerate in the archaeon Methanococcoides burtonii". Journal of Bacteriology. 188 (3): 1022–30. doi:10.1128/JB.188.3.1022-1030.2006. PMC 1347341. PMID 16428406.
- ^ Empadinhas N, Albuquerque L, Mendes V, Macedo-Ribeiro S, da Costa MS (March 2008). "Identification of the mycobacterial glucosyl-3-phosphoglycerate synthase". FEMS Microbiology Letters. 280 (2): 195–202. doi:10.1111/j.1574-6968.2007.01064.x. PMID 18221489.
- ^ Pereira PJ, Empadinhas N, Albuquerque L, Sá-Moura B, da Costa MS, Macedo-Ribeiro S (2008). Song H (ed.). "Mycobacterium tuberculosis glucosyl-3-phosphoglycerate synthase: structure of a key enzyme in methylglucose lipopolysaccharide biosynthesis". PLOS ONE. 3 (11): e3748. Bibcode:2008PLoSO...3.3748P. doi:10.1371/journal.pone.0003748. PMC 2581804. PMID 19015727.
- ^ Gest P, Kaur D, Pham HT, van der Woerd M, Hansen E, Brennan PJ, Jackson M, Guerin ME (December 2008). "Preliminary crystallographic analysis of GpgS, a key glucosyltransferase involved in methylglucose lipopolysaccharide biosynthesis in Mycobacterium tuberculosis". Acta Crystallographica Section F. 64 (Pt 12): 1121–4. doi:10.1107/S1744309108032892. PMC 2593697. PMID 19052364.
- ^ Kaur D, Pham H, Larrouy-Maumus G, Rivière M, Vissa V, Guerin ME, Puzo G, Brennan PJ, Jackson M (2009). Herman C (ed.). "Initiation of methylglucose lipopolysaccharide biosynthesis in mycobacteria". PLOS ONE. 4 (5): e5447. Bibcode:2009PLoSO...4.5447K. doi:10.1371/journal.pone.0005447. PMC 2674218. PMID 19421329.
External links
edit- Glucosyl-3-phosphoglycerate+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
