Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase (EC 2.4.1.175, N-acetylgalactosaminyltransferase II, UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase, chondroitin synthase, glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II) is an enzyme with systematic name UDP-N-acetyl-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
| Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.4.1.175 | ||||||||
| CAS no. | 96189-40-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- UDP-N-acetyl-D-galactosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan
This enzyme is involved in the biosynthesis of chondroitin sulfate.
References
edit- ^ Rohrmann K, Niemann R, Buddecke E (May 1985). "Two N-acetylgalactosaminyltransferase are involved in the biosynthesis of chondroitin sulfate". European Journal of Biochemistry. 148 (3): 463–9. doi:10.1111/j.1432-1033.1985.tb08862.x. PMID 3922754.
- ^ Kitagawa H, Uyama T, Sugahara K (October 2001). "Molecular cloning and expression of a human chondroitin synthase". The Journal of Biological Chemistry. 276 (42): 38721–6. doi:10.1074/jbc.M106871200. PMID 11514575.
- ^ DeAngelis PL, Padgett-McCue AJ (August 2000). "Identification and molecular cloning of a chondroitin synthase from Pasteurella multocida type F". The Journal of Biological Chemistry. 275 (31): 24124–9. doi:10.1074/jbc.M003385200. PMID 10818104.
- ^ Ninomiya T, Sugiura N, Tawada A, Sugimoto K, Watanabe H, Kimata K (June 2002). "Molecular cloning and characterization of chondroitin polymerase from Escherichia coli strain K4". The Journal of Biological Chemistry. 277 (24): 21567–75. doi:10.1074/jbc.M201719200. PMID 11943778.
External links
edit- Glucuronosyl-N-acetylgalactosaminyl-proteoglycan+4-beta-N-acetylgalactosaminyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
