Glutamate synthase (ferredoxin)

In enzymology, a glutamate synthase (ferredoxin) (EC 1.4.7.1) is an enzyme that catalyzes the chemical reaction

glutamate synthase (ferredoxin)
Identifiers
EC no.	1.4.7.1
CAS no.	62213-56-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

2 L-glutamate + 2 oxidized ferredoxin $\rightleftharpoons$ L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H⁺

Thus, the two substrates of this enzyme are L-glutamate and oxidized ferredoxin, whereas its 4 products are L-glutamine, 2-oxoglutarate, reduced ferredoxin, and H⁺.

Classification

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH₂ group of donors with an iron-sulfur protein as acceptor.

Nomenclature

The systematic name of this enzyme class is L-glutamate:ferredoxin oxidoreductase (transaminating). Other names in common use include:

• ferredoxin-dependent glutamate synthase,
• ferredoxin-glutamate synthase,
• glutamate synthase (ferredoxin-dependent), and
• ferredoxin-glutamine oxoglutarate aminotransferase (Fd-GOGAT).

Biological role

This enzyme participates in nitrogen metabolism. It has 5 cofactors: FAD, iron, sulfur, iron-sulfur, and flavoprotein.

See also

• Glutamate synthase (NADH)
• Glutamate synthase (NADPH)

References

• Jang JE, Shaw K, Yu XJ, Petersen D, Pepper K, Lutzko C, Kohn DB (2006). "Specific and stable gene transfer to human embryonic stem cells using pseudotyped lentiviral vectors". Stem Cells Dev. 15 (1): 109–17. doi:10.1089/scd.2006.15.109. PMID 16522168.
• Lea PJ, Miflin BJ (1974). "Alternative route for nitrogen assimilation in higher plants". Nature. 251 (5476): 614–6. Bibcode:1974Natur.251..614L. doi:10.1038/251614a0. PMID 4423889. S2CID 4184284.