Glycine/sarcosine/dimethylglycine N-methyltransferase (EC 2.1.1.162, GSDMT, glycine sarcosine dimethylglycine N-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:glycine(or sarcosine or N,N-dimethylglycine) N-methyltransferase (sarcosine(or N,N-dimethylglycine or betaine)-forming).[1] This enzyme catalyses the following chemical reaction
| Glycine/sarcosine/dimethylglycine N-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.162 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- 3 S-adenosyl-L-methionine + glycine 3 S-adenosyl-L-homocysteine + betaine (overall reaction)
- (1a) S-adenosyl-L-methionine + glycine S-adenosyl-L-homocysteine + sarcosine
- (1b) S-adenosyl-L-methionine + sarcosine S-adenosyl-L-homocysteine + N,N-dimethylglycine
- (1c) S-adenosyl-L-methionine + N,N-dimethylglycine S-adenosyl-L-homocysteine + betaine
This enzyme from the halophilic methanoarchaeon Methanohalophilus portucalensis can methylate glycine and all of its intermediates to form the compatible solute trimethylglycine.
References
edit- ^ Lai MC, Wang CC, Chuang MJ, Wu YC, Lee YC (December 2006). "Effects of substrate and potassium on the betaine-synthesizing enzyme glycine sarcosine dimethylglycine N-methyltransferase from a halophilic methanoarchaeon Methanohalophilus portucalensis". Research in Microbiology. 157 (10): 948–55. doi:10.1016/j.resmic.2006.08.007. PMID 17098399.
External links
edit- Glycine/sarcosine/dimethylglycine+N-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
