Glycine/sarcosine/dimethylglycine N-methyltransferase

Glycine/sarcosine/dimethylglycine N-methyltransferase (EC 2.1.1.162, GSDMT, glycine sarcosine dimethylglycine N-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:glycine(or sarcosine or N,N-dimethylglycine) N-methyltransferase (sarcosine(or N,N-dimethylglycine or betaine)-forming).[1] This enzyme catalyses the following chemical reaction

Glycine/sarcosine/dimethylglycine N-methyltransferase
Identifiers
EC no.2.1.1.162
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins
3 S-adenosyl-L-methionine + glycine 3 S-adenosyl-L-homocysteine + betaine (overall reaction)
(1a) S-adenosyl-L-methionine + glycine S-adenosyl-L-homocysteine + sarcosine
(1b) S-adenosyl-L-methionine + sarcosine S-adenosyl-L-homocysteine + N,N-dimethylglycine
(1c) S-adenosyl-L-methionine + N,N-dimethylglycine S-adenosyl-L-homocysteine + betaine

This enzyme from the halophilic methanoarchaeon Methanohalophilus portucalensis can methylate glycine and all of its intermediates to form the compatible solute trimethylglycine.

References

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  1. ^ Lai MC, Wang CC, Chuang MJ, Wu YC, Lee YC (December 2006). "Effects of substrate and potassium on the betaine-synthesizing enzyme glycine sarcosine dimethylglycine N-methyltransferase from a halophilic methanoarchaeon Methanohalophilus portucalensis". Research in Microbiology. 157 (10): 948–55. doi:10.1016/j.resmic.2006.08.007. PMID 17098399.
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