In enzymology, a glycolipid 3-alpha-mannosyltransferase (EC 2.4.1.132) is an enzyme that catalyzes the chemical reaction in which an alpha-D-mannosyl residue is transferred from GDP-mannose to a lipid-linked oligosaccharide, being attached by an alpha-1,3-D-mannosyl-D-mannose bond.
| glycolipid 3-alpha-mannosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.4.1.132 | ||||||||
| CAS no. | 81181-76-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-mannose:glycolipid 1,3-alpha-D-mannosyltransferase. Other names in common use include mannosyltransferase II, guanosine diphosphomannose-oligosaccharide-lipid II, mannosyltransferase, and GDP-mannose-oligosaccharide-lipid mannosyltransferase II. This enzyme participates in the biosynthesis of n-glycan and glycan structures.
References
edit- Jensen JW, Schutzbach JS (1981). "The biosynthesis of oligosaccharide-lipids. Partial purification and characterization of mannosyltransferase II". J. Biol. Chem. 256 (24): 12899–904. PMID 7309740.
