Glycoprotein N-palmitoyltransferase

In enzymology, a glycoprotein N-palmitoyltransferase (EC 2.3.1.96) is an enzyme that catalyzes the chemical reaction

glycoprotein N-palmitoyltransferase
Identifiers
EC no.2.3.1.96
CAS no.97162-74-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
palmitoyl-CoA + glycoprotein CoA + N-palmitoylglycoprotein

Thus, the two substrates of this enzyme are palmitoyl-CoA and glycoprotein, whereas its two products are CoA and N-palmitoylglycoprotein.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is palmitoyl-CoA:glycoprotein N-palmitoyltransferase. This enzyme is also called mucus glycoprotein fatty acyltransferase. This enzyme participates in aminosugars metabolism. This enzyme has at least one effector, Dithiothreitol.

References

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  • Liau YH, Slomiany BL, Slomiany A, Piasek A, Palmer D, Rosenthal WS (1985). "Identification of mucus glycoprotein fatty acyltransferase activity in human gastric mucosa". Digestion. 32 (1): 57–62. doi:10.1159/000199218. PMID 4018446.