Glycylpeptide N-tetradecanoyltransferase 2

Glycylpeptide N-tetradecanoyltransferase 2 known also as N-myristoyltransferase, is an enzyme (EC: 2.3.1.97) that in humans is encoded by the NMT2 gene.

Human N-myristoyltransferase 2
Human N-myristoyltransferase isoform 2 (NMT2) (based on PDB: 4c2x)
Identifiers
Symbol	NMT2
Pfam	PF01233
InterPro	IPR022676
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

NMT2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4C2X
Identifiers
Aliases	NMT2, N-myristoyltransferase 2
External IDs	OMIM: 603801; MGI: 1202298; HomoloGene: 101539; GeneCards: NMT2; OMA:NMT2 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10p13 Start 15,102,584 bp End 15,168,693 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 A1 Start 3,285,249 bp End 3,329,914 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell ventricular zone adipose tissue subcutaneous adipose tissue cerebellar hemisphere ganglionic eminence right hemisphere of cerebellum abdominal fat tibia lateral nuclear group of thalamus Top expressed in cumulus cell substantia nigra Rostral migratory stream medial dorsal nucleus medullary collecting duct medial geniculate nucleus atrioventricular valve retinal pigment epithelium lateral geniculate nucleus condyle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity acyltransferase activity glycylpeptide N-tetradecanoyltransferase activity Cellular component cytoplasm plasma membrane Golgi apparatus membrane extrinsic component of membrane cytosol host cell Biological process regulation of rhodopsin mediated signaling pathway intracellular transport of virus N-terminal protein myristoylation N-terminal peptidyl-glycine N-myristoylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9397 18108 Ensembl ENSG00000152465 ENSMUSG00000026643 UniProt O60551 O70311 RefSeq (mRNA) NM_001308295 NM_004808 NM_001290368 NM_001290369 NM_001290370 NM_008708 RefSeq (protein) NP_001295224 NP_004799 NP_001277297 NP_001277298 NP_001277299 NP_032734 Location (UCSC) Chr 10: 15.1 – 15.17 Mb Chr 2: 3.29 – 3.33 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

N-myristoyltransferase (NMT) catalyzes the reaction of N-terminal myristoylation of many signaling proteins. It transfers myristic acid from myristoyl coenzyme A to the amino group of a protein's N-terminal glycine residue. Biochemical evidence indicates the presence of several distinct NMTs, varying in apparent molecular weight and /or subcellular distribution. The 496-amino acid of human NMT2 protein shares 77% and 96% sequence identity with human NMT1 and mouse Nmt2 comprise two distinct families of N-myristoyltransferases.

Interactions

NMT2 has been shown to interact with:

• caspase 3
• MARCKS

See also

• N-myristoyltransferase 1

Further reading

• Kolluri SK, Balduf C, Hofmann M, Göttlicher M (2002). "Novel target genes of the Ah (dioxin) receptor: transcriptional induction of N-myristoyltransferase 2". Cancer Res. 61 (23): 8534–9. PMID 11731439.
• Wright MH, Clough B, Rackham MD, Rangachari K, Brannigan JA, Grainger M, Moss DK, Bottrill AR, Heal WP, Broncel M, Serwa RA, Brady D, Mann DJ, Leatherbarrow RJ, Tewari R, Wilkinson AJ, Holder AA, Tate EW (2014). "Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach". Nat Chem. 6 (2): 112–21. Bibcode:2014NatCh...6..112W. doi:10.1038/nchem.1830. PMC 4739506. PMID 24451586.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Glycylpeptide N-tetradecanoyltransferase 2 (NMT2)