Go 6976 (also known as Go-6976 and Goe 6976) is an organic protein kinase inhibitor.[1][2] It has some specificity for protein kinase C alpha and beta, and through their inhibition it is thought to induce the formation of cell junctions, and hence inhibit the invasion of urinary bladder carcinoma cells".[3]
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| Preferred IUPAC name
3-(13-Methyl-5-oxo-5,6,7,13-tetrahydro-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12-yl)propanenitrile | |
| Other names
PD 406976
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| Identifiers | |
3D model (JSmol)
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| 8588138 | |
| ChEBI | |
| ChEMBL | |
| ChemSpider | |
PubChem CID
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| UNII | |
CompTox Dashboard (EPA)
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| Properties | |
| C24H18N4O | |
| Molar mass | 378.435 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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References
edit- ^ "NCATS Inxight: Drugs — GO-6976". drugs.ncats.io. U.S.: NCATS, United States Department of Health and Human Services. Retrieved 2019-09-29.
- ^ Qatsha, KA; Rudolph, C; Marmé, D; Schaechtele, C.; May, MD,PhD, W. (1993-06-01). "Go 6976, a selective inhibitor of protein kinase C, is a potent antagonist of human immunodeficiency virus 1 induction from latent/low-level-producing reservoir cells in vitro". Proceedings of the National Academy of Sciences. 90 (10): 4674–8. Bibcode:1993PNAS...90.4674Q. doi:10.1073/pnas.90.10.4674. PMC 46575. PMID 7685108.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Koivunen, Jussi; Aaltonen, Vesa; Koskela, Sanna; Lehenkari, Petri; Laato, Matti; Peltonen, Juha (2004-08-15). "Protein kinase C alpha/beta inhibitor Go6976 promotes formation of cell junctions and inhibits invasion of urinary bladder carcinoma cells". Cancer Research. 64 (16): 5693–5701. doi:10.1158/0008-5472.CAN-03-3511. ISSN 0008-5472. PMID 15313909.