Gosain, Gossain, Gosine, Gosyne, Gossai is an Indian surname. Notable people with the surname include:
- Satpal Gosain (1935–2020), Indian politician
- Shivani Gosain (born 1975), Indian actress
- Suhit Gosain (born 1985), Indian pop singer, actor, and performer
- Jagat Gosain (1573-1619), Indian Mughal empress, daughter of Udai Singh of Marwar, wife of Jahangir, and mother of Shah Jahan