Gougerotin is a water-soluble pyrimidine-based antibiotic which is produced by the bacteria Streptomyces graminearus and Streptomyces gougerotii.[1][2][3][4] Gougerotin is named after the dermatologist Henri-Eugène Gougerot.[2] Gougerotin has activity against Gram-positive and Gram-negative bacteria as well as against viruses.[2]
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| Formula | C16H25N7O8 |
| Molar mass | 443.417 g·mol−1 |
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References
edit- ^ Yukioka M (1975). "Gougerotin". Mechanism of Action of Antimicrobial and Antitumor Agents. pp. 448–458. doi:10.1007/978-3-642-46304-4_29. ISBN 978-3-642-46306-8.
- ^ a b c "Gougerotin". www.spektrum.de (in German).
- ^ Comprehensive Natural Products III. Elsevier. 22 July 2020. p. 528. ISBN 978-0-08-102691-5.
- ^ "Gougerotin". www.spektrum.de (in German).
Further reading
edit- Clark JM, Gunther JK (December 1963). "Gougerotin, a specific inhibitor of protein synthesis". Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects. 76: 636–8. doi:10.1016/0926-6550(63)90092-6. PMID 14099625.
- Burkett AR, Schlender KK, Sell HM (March 1970). "Gougerotin—an inhibitor of protein synthesis and auxin-induced elongation in plants". Phytochemistry. 9 (3): 545–547. Bibcode:1970PChem...9..545B. doi:10.1016/S0031-9422(00)85687-3.
- Gottlieb D, Shaw PD (6 December 2012). Mechanism of Action. Springer Science & Business Media. p. 281. ISBN 978-3-642-46051-7.
- Barbacid M, Vazquez D (May 1974). "(G-3H)gougerotin binding to ribosomes. Heterogeneity of eukaryotic ribosomes". European Journal of Biochemistry. 44 (2): 445–53. doi:10.1111/j.1432-1033.1974.tb03502.x. PMID 4600364.