Granulomatous prostatitis is an uncommon disease of the prostate, an exocrine gland of the male reproductive system.[1] It is a form of prostatitis (prostate inflammation), resulting from infection (bacterial, viral, or fungal), BCG vaccine, malacoplakia or systemic granulomatous diseases which involve the prostate.
| Granulomatous prostatitis | |
|---|---|
 | |
| Micrograph showing a granulomatous prostatitis due to BCG treatment for bladder cancer. H&E stain. | |
| Specialty | Urology |
Pathogenesis
editProstatic secretions escape into the stroma and elicit an inflammatory response.[2]
Histopathology
editNoticeable destruction of Acini, surrounded by epitheloid cells, giant cells, lymphocytes, plasma cells and dense fibrosis.[2]
Mimicry of prostate cancer
editGranulomatous prostatitis can be mistaken for prostate cancer, including on rectal examination, MRI and heightened PSA scores. A biopsy differentiates.[3][4][5][6]
Causes
editSome 70% of cases are idiopathic. Causes may include infection and immunological links.[6]
Prevalence
editOne study stated prevalence in 0.44% in routine prostectomy specimens, 0.29% in needle biopsies and 0.77% of TURP, simple prostatectomy and needle biopsy.[2]
References
edit- ^ "Granulomatous prostatitis". MedGen. NCBI.
- ^ a b c Kumbar, Rajeshwari (2016). "Clinicopathological Overview of Granulomatous Prostatitis: An Appraisal". Journal of Clinical and Diagnostic Research. 10 (1). JCDR Research and Publications: EC20-3. doi:10.7860/jcdr/2016/15365.7146. ISSN 2249-782X. PMC 4740601. PMID 27014642.
- ^ Bertelli, Elena; Zantonelli, Giulia; Cinelli, Alberto; Pastacaldi, Sandro; Agostini, Simone; Neri, Emanuele; Miele, Vittorio (23 September 2022). "Granulomatous Prostatitis, the Great Mimicker of Prostate Cancer: Can Multiparametric MRI Features Help in This Challenging Differential Diagnosis?". Diagnostics. 12 (10): 2302. doi:10.3390/diagnostics12102302. PMC 9600901. PMID 36291991.
- ^ "Nonspecific granulomatous prostatitis".
- ^ Luca, Luigi De; Crocetto, Felice; Barone, Biagio; Creta, Massimiliano; Pesce, Salvatore; Aveta, Achille; Campanino, Maria Raffaela; Imbimbo, Ciro; Longo, Nicola (August 2020). "Granulomatous prostatitis mimicking prostate cancer in a patient with psoriatic arthritis: a case report". Future Science OA. 6 (7): FSO591. doi:10.2144/fsoa-2020-0031. PMC 7421716. PMID 32802396.
- ^ a b Hulman, Geoffrey (25 January 2023). "Granulomatous Prostatitis - Pathology mini tutorial". YouTube.[user-generated source?]