Guaifenesin/phenylephrine is a combination of the drugs guaifenesin and phenylephrine and is a preparation against the symptoms of cold, flu and allergy. Guaifenesine is an expectorant, phenylephrine is a decongestant. The drug is sold under the brand name Entex and as generic brands. Entex La is 400 mg guaifenesin and 30 mg phenylephrine hydrochloride. Entex Pse is 600 mg guaifenesin and 120 mg phenylephrine hydrochloride. Both are extended release products, meaning that the non-active ingredients are chosen to dissolve slowly to provide a prolonged therapeutic effect.[citation needed]
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| Guaifenesin | Expectorant |
| Phenylephrine | α1-adrenergic receptor agonist |
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| Routes of administration | By mouth |
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Guaifenesin
editGuaifenesin is an oral medication used to try to help cough out phlegm from the airways.[1] It is often used in combination with other medications.[1] It is believed to work by making airway secretions more liquid.[1] Side effects may include dizziness, sleepiness, skin rash, and nausea.[2] Guaifenesin has been used medically since at least 1933.[3] It is available as a generic medication and an over-the-counter drug.[1][4]
Phenylephrine
editPhenylephrine is an oral medication primarily used as a decongestant.[5][6] It is a selective α1-adrenergic receptor activator which results in the constriction of both arteries and veins.[5] Common side effects include nausea, headache, and anxiety.[5] Phenylephrine was patented in 1927 and came into medical use in 1938.[7] It is available as a generic medication.[6]
References
edit- ^ a b c d "Guaifenesin Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 25 March 2019.
- ^ "Guaifenesin". Drugs.com. Retrieved 2019-03-25.
- ^ Riviere JE, Papich MG (2013). Veterinary Pharmacology and Therapeutics. John Wiley & Sons. p. 287. ISBN 9781118685907.
- ^ Weiner CP, Rope K (2013). The Complete Guide to Medications During Pregnancy and Breastfeeding: Everything You Need to Know to Make the Best Choices for You and Your Baby. St. Martin's Press. p. PT282. ISBN 9781250037206.
- ^ a b c "Phenylephrine Hydrochloride Monograph for Professionals". Drugs.com. AHFS. Retrieved 10 January 2019.
- ^ a b British national formulary : BNF 76 (76, 1140 ed.). Pharmaceutical Press. 2018. pp. 188–189. ISBN 9780857113382.
- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 541. ISBN 9783527607495.
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