Guanosine phosphorylase

In enzymology, a guanosine phosphorylase (EC 2.4.2.15) is an enzyme that catalyzes the chemical reaction

guanosine phosphorylase
Identifiers
EC no.2.4.2.15
CAS no.9030-28-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins
guanosine + phosphate guanine + alpha-D-ribose 1-phosphate

Thus, the two substrates of this enzyme are guanosine and phosphate, whereas its two products are guanine and alpha-D-ribose 1-phosphate.

This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is guanosine:phosphate alpha-D-ribosyltransferase. This enzyme participates in purine metabolism.[1]

References

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  1. ^ Koszalka, G W; Vanhooke, J; Short, S A; Hall, W W (August 8, 1988). "Purification and properties of inosine-guanosine phosphorylase from Escherichia coli K-12". Journal of Bacteriology. 170 (8): 3493–3498. doi:10.1128/jb.170.8.3493-3498.1988. ISSN 0021-9193. PMC 211319.
  • Yamada EW (November 1961). "The phosphorolysis of nucleosides by rabbit bone marrow". The Journal of Biological Chemistry. 236: 3043–6. PMID 14008731.