Guanylate binding protein family member 6

GBP6
Identifiers
Aliases	GBP6, guanylate binding protein family member 6
External IDs	OMIM: 612467; MGI: 97072; HomoloGene: 128731; GeneCards: GBP6; OMA:GBP6 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	89,388,160 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	105,287,452 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; mucosa of pharynx; ; oral cavity; ; mucosa of esophagus; ; body of tongue; ; superior surface of tongue; ; epithelium of nasopharynx; ; tonsil; ; vulva; ; vagina;
	Top expressed in
	thymus; ; spleen; ; lung; ; heart; ; pancreas; ; islet of Langerhans; ; jejunum; ; ileum; ; muscle tissue; ; ovary;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; GTP binding; GTPase activity;
Cellular component	extracellular exosome; symbiont-containing vacuole membrane; cytoplasmic vesicle;
Biological process	defense response to bacterium; immune response; cellular response to interferon-gamma; defense response to protozoan; defense response to Gram-positive bacterium;
	Sources:Amigo / QuickGO
Orthologs
	163351
	17472
	ENSG00000183347
	ENSMUSG00000079363
	Q6ZN66
	n/a
	NM_198460; NM_001320257
NM_001256005; NM_008620; NM_001359079; NM_001359080; NM_001359081;
	NM_001359082
	NP_001307186; NP_940862
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Guanylate binding protein family member 6 is a protein that in humans is encoded by the GBP6 gene. ^[5]

Function

Guanylate-binding proteins, such as GBP6, are induced by interferon and hydrolyze GTP to both GDP and GMP (Olszewski et al., 2006 [PubMed 16689661]).

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183347 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000079363 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Guanylate binding protein family member 6". Retrieved 2017-07-27.